【摘要】 <正>骨肉瘤（osteosarcoma,OS）是最常见的原发性恶性骨肿瘤,约占全部骨肿瘤的15%,好发于儿童和青少年^[1]。OS的传统治疗方法主要是高位截肢治疗,随着影像学、辅助化疗、外科技术及生物力学工程学的发展,自20世纪80年代以来,OS的治疗由单纯高位截肢术发展为以保肢手术、新辅助化疗相结合的综合保肢治疗,OS患者的截肢率显著降低、5年生存率较过往有所提高,然而,尽更多还原

【Abstract】 Osteosarcoma is the most common primary cancer derived from bone tissues, which is frequently found in adolescents and children. The extensive application of the comprehensive limb salvage treatment reduces the amputation rate significantly, and the five-year survival rate is higher. But the prognosis of chemotherapy-resistant patients is still poor. It is very important to improve the prognosis of osteosarcoma by clarifying the pathogenesis of drug resistance. In this paper, we review the mechanism of osteosarcoma chemoresistance, including the non-coding RNA disorders, gene, DNA repair, cancer stem cells, autophagy and tumor microenvironment ect. We also summarize the deficiencies in the current studies about osteosarcoma chemoresistance and hope to improve osteosarcoma chemotherapy sensitivity.更多还原