【摘要】 目的回顾性分析异甘草酸镁治疗混合型药物性肝损伤(drug-induced liver injury,DILI)的临床疗效。方法采用同期非随机对照法分析2014年1月至2016年12月于青岛市市立医院住院的60例混合型DILI患者的临床资料。对照组患者(28例)采用常规的保肝、降酶、退黄治疗,治疗组患者(32例)在对照组的基础上加用异甘草酸镁(200 mg/d,静脉滴注)治疗,疗程均为4周。观察两组患者治疗1周、2周及4周后临床症状及生物化学指标的变化,分析异甘草酸镁对混合型DILI的疗效。结果治疗后两组患者的临床症状、体征和肝生物化学指标较治疗前均有显著改善。第1周开始,治疗组患者血清AST、ALT水平的下降差值显著大于对照组(P均<0.05),GGT下降差值于第2周显著大于对照组(P均<0.05),ALP下降差值于治疗第4周显著大于对照组(t=5.439,P<0.001)。治疗组的总有效率(93.75%)显著高于对照组(75.00%),差异有统计学意义(χ~2=4.118,P=0.042)。结论异甘草酸镁可加快混合型DILI患者血清AST、ALT、GGT和ALP水平的恢复,疗效较好。更多还原

【Abstract】 Objective To investigate clinical efficacy of Magnesium Isoglycyrrhizin on mixed drug-induced liver injury(DILI), retrospectively. Methods A retrospective non-randomly case-control study was carried out to analyze the clinical data of 60 patients who were diagnosed as mixed DILI in Qingdao Municipal Hospital from January 2014 to December 2016. The patients were divided into two groups depending on therapeutic regimens. Patients in control group were given conventional treatment such as liver protection, enzyme degradation and jaundice and patients in treatment group were given Magnesium Isoglycyrrhizin(200 mg/d, intravenous drip) on the basis of control group. The course of treatment was 4 weeks. Improvements of clinical manifestations and liver biochemical markers were observed at 1 week, 2 weeks and 4 weeks, the clinical efficacy of Magnesium Isoglycyrrhizin was also analyzed. Results After treatment, clinical symptoms and liver biochemical markers improved significantly in both groups. The drop-out values of AST and ALT of patients in treatment group were significantly higher than those of control group at 1 week(P < 0.05). The drop-out values of GGT were significantly higher than those of control group at 2 weeks(P < 0.05) and the drop-out value of ALP were significantly higher than that of control group at 4 weeks(t = 5.439, P < 0.001). The total effective rate in treatment group(93.75%) was significantly higher than that of control group(75.00%), with statistical significance(t = 5.439, P < 0.001). Conclusion Magnesium Isoglycyrrhizin is effective in the treatment of mixed DILI through promoting AST, ALT, GGT and ALP.更多还原