【摘要】 我国是HBV感染高发地区,由HBV感染引起的肝硬化(liver cirrhosis,LC)和肝细胞癌(hepatocellular carcinoma,HCC)分别占LC和HCC的60%和80%,我国HCC患者占世界HCC患者的53.5%。我国HBV感染约一半是通过母婴传播形成的。因此,阻断HBV母婴传播具有重要意义。本文通过综述HBV DNA载量、HBV基因型、HBV耐药、ALT和AST与母婴传播的关系,应用"精准医疗"的理念,提出了以HBV宫内感染为基础的精准阻断理念,以期为进一步科学阻断HBV母婴传播提供参考。更多还原

【Abstract】 China has a high prevalence of hepatitis B virus(HBV) infection. Liver cirrhosis(LC) and hepatocellular carcinoma(HCC) caused by HBV infection accounted for 60% and 80% of all HC and HCC patients, respectively. Patients with HCC in China accounted for 53.5% of the world. Half of patients with HBV infection were transmitted through mother-to-child route. Blocking mother-to-child transmission of HBV has important social and economic significance. This review summarized the relationship between HBV DNA load, viral genotype, drug resistance, chronic hepatitis activity and mother-to-child transmission. Referring to the precision medicine, we proposed the precision concept of blocking mother-to-child transmission based on HBV intrauterine infection, in order to provide theoretical basis for further study of blocking HBV mother-to-child transmission.更多还原