【摘要】 目的了解2012²015年梧州市新生儿先天性甲状腺功能减低症（CH）的筛查、治疗及随访情况。方法选择梧州市2012年1月至2015年12月间出生的240 556活产婴儿,了解CH筛查情况、使用左旋甲状腺素钠片（L-T₄）治疗高促甲状腺素血症及CH的效果。结果接受CH筛查的新生儿223 581例,筛查率为92.94%,筛查阳性率为0.85%,召回率为98.05%。高促甲状腺素血症发病率为72.46/10万,CH发病率为52.33/10万。117例CH患儿使用L-T₄治疗,其中治愈43例（36.75%）,继续治疗51例（43.59%）,转诊4例（3.42%）,诊断为永久性甲状腺功能减低症14例（11.97%）,失访5例（4.27%）。99例高促甲状腺素血症患儿使用L-T₄治疗,其中治愈51例（51.52%）,继续治疗43例（43.43%）,转诊2例（2.02%）,失访3例（3.03%）。L-T₄不良反应发生率6.48%（14/216）,均可自行缓解。随访治疗期间261例（98.49%）患儿体格、智力发育正常。结论 2012²015年梧州市CH发病率较高;L-T₄治疗CH疗效确切。更多还原

【Abstract】 Objective To investigate the screening,treatment and follow-up of congenital hypothyroidism（ CH） among newborns in Wuzhou City from 2012 to 2015. Methods A total of 240,556 live infants born in Jan. 2012 to Dec. 2015 in Wuzhou City were selected. The incidence of CH was investigated. And the efficacy of levothyroxine sodium tablets（ L-T₄） on the hyperthyrotropinemia and CH was observed.Results A total of 223,581 newborns received the screening for CH,and the screening rate was 92. 94%. The positive rate of screening was 0. 85% and the recall rate was 98. 05%. The incidence rates of hyperthyrotropinemia and CH were 72. 46/100,000 and 52. 33/100,000 respectively. Of 117 CH newborns with the treatment of L-T₄,43 cases were cured（ 36. 75%）,51 received continuous therapy（ 43. 59%）,4 accepted referral（ 3. 42%）,14 were diagnosed as permanent hypothyroidism（ 11. 97%）,and 5 were lost to follow-up（ 4. 27%）. Of 99 hyperthyrotropinemia newborns with treatment of L-T₄,51 cases were cured（ 51. 52%）,43 received continuous therapy（ 43. 43%）,2accepted referral（ 2. 02%）,and 3 were lost to follow-up（ 3. 03%）. The adverse reaction incidence rate of L-T₄ was 6. 48%（ 14/216）,and the adverse reactions subsided spontaneously. Normal physical and mental development were observed in 261 newborns（ 98. 49%） during the follow-up. Conclusion The incidence rate of CH was relatively high in Wuzhou City from 2012 to 2015,and L-T₄ obtains a definite efficacy on CH.更多还原