【摘要】 目的分析消化道颗粒细胞瘤(GCT)患者的临床特征,对治疗效果进行分析。方法回顾分析2012年12月~2016年10月在我院住院的5例消化道GCT患者的临床资料,分析其临床特征,治疗效果。结果 5例消化道GCT患者中,食管GCT4例(其中1例合并早期食管癌),盲肠GCT 1例,所有患者均表现为非特异性消化道症状或无消化道症状,均行术前内镜及超声内镜检查诊断为消化道黏膜下隆起性病变,分别疑诊脂肪瘤、类癌及异位胰腺。1例术前考虑消化道GCT,5例患者术前均未活检,4例行内镜下黏膜剥离术(ESD),1例行单环套扎+圈套器切除,术后病理及免疫组化分析显示肿瘤细胞均表达S-100,确诊为消化道GCT,未见明显恶性特征,术后随访3~48个月,均无复发及转移。结论消化道GCT可无特异性消化道症状、发病率低,内镜下亦无特异性表现,因此明确诊断仍依赖于病理结果,对于<2cm的黏膜下GCT,内镜下治疗效果好,但需长期随访,排除恶变可能。更多还原

【Abstract】 Objective To explore the clinical characteristicas of granular cell tuomr, and to analyze the curative effect. Methods Data of 5 cases of GCT patients cured in our hospital from December 2012 to October 2016 were retrospectively analyzed. The clinical characteristics and therapeutic effect were analyzed. Results Among the 5 cases of GCT patients, there were GCT4 cases of esophagus(1 cases with early esophageal cancer) and GCT of cecum in 1 cases. All patients presented with nonspecific gastrointestinal symptoms or no gastrointestinal symptoms. All cases were diagnosed by endoscopic and endoscopic ultrasonography, and they respectively were lipoma, carcinoid and ectopic pancreas. 1 cases of gastrointestinal tract GCT were considered before operation, and all of the 5 patients had no biopsy before operation, and endoscopic mucosal resection(ESD) was performed in all of the 4 patients, and the other cases were treated with single loop ligation and snare excision(n=1). Postoperative pathological and immunohistochemical analysis showed that the tumor cells all expressed S-100, which was diagnosed as digestive tract GCT, and there was no obvious malignant feature. No recurrence and metastasis were observed after 3-48 months of follow-up. Conclusion There are no specific gastrointestinal symptoms and low incidence of GCT in the digestive tract. Therefore, the definite diagnosis depends on pathological results. For less than 2cm of submucosal GCT, endoscopic treatment effect is good, but need long-term follow-up, exclude the possibility of malignancy.更多还原