【摘要】 目的:探讨供/受者体表面积(BSA)比对公民器官捐献(DCD)肾移植术后受者早期肾功能康复的影响。方法:回顾性分析2011年3月至2016年3月在湖南省益阳市中心医院治疗的101例DCD肾移植术受者的临床资料,根据供/受者BSA比值分为3组:BSA比值≤0.8为A组(n=26),0.8<BSA比值<1.2为B组(n=55),BSA比值≥1.2为C组(n=20)。随访统计术后1周、1个月、3个月、6个月、12个月受者的肾功能康复情况。结果:术后1周至12个月内各时间点,C组血清肌酐(Scr)均显著低于A组,而肾小球滤过率(eGFR)显著高于A组(均P<0.05);术后6个月、12个月,C组的Scr显著低于B组,而eGFR显著高于B组(均P<0.05);B组、C组术后早期肾功能康复率显著高于A组(P<0.05);术后12个月内,3组急性排斥反应(AR)发生率比较,差异无统计学意义(P>0.05),而B组、C组的移植肾功能延迟恢复(DGF)发生率显著低于A组(P<0.05),但B组、C组间比较,差异无统计学意义(P>0.05)。结论:供/受者BSA比值可影响DCD肾移植术后受者早期肾功能康复,BSA比值>0.8更有利于受者术后肾功能康复。更多还原

【Abstract】 Objective:To investigate the effect of donor/recipient body surface area(BSA)ratio on the rehabilitation of renal function of potential recipient after renal transplantation from donation after citizen death(DCD).Methods:The clinical data of 101 potential recipients after renal transplantation from DCD were retrospectively analyzed,and divided into three groups according to the donor/recipient BSA ratio:group A with BSA ratio≤0.8(n=26),group B with BSA ratio ranged from 0.8to 1.2(n=55)and group C with BSA ratio≥1.2(n=20).The serum level of Scr and graft eGFR at 1week,3,6and 12 months post-operation were recorded respectively.Results:At each time point after renal transplantation,the serum level of Scr in group C was significantly lower than that in group A,while the graft eGFR was significantly higher(P<0.05).At 6and 12 months after renal transplantation,the serum level of Scr in group C was significantly lower than that in group B,while the graft eGFR was significantly higher(P<0.05).The post-operation early renal function recovery rate in group B and C were significantly higher than that in group A(P<0.05).At 12 months after operation,the acute rejection(AR)rate in three groups showed no significant deference(P>0.05),but the graft delay recovery(DGF)rate in group B and C was significantly lower than that in group A(P<0.05),but there was no significant difference between group B and group C(P>0.05).Conclusion:The donor/recipient BSA ratio could affect the rehabilitation of renal function of potential recipient after renal transplantation from DCD.BSA ratio>0.8could achieve a better postoperative renal transplantation of potential recipient.更多还原