【摘要】 为研究常见临床检测指标糖尿病慢性肾脏疾病诊断率的影响,本次研究选取了143例Ⅱ型糖尿病患者,按照尿白蛋白排泄率(UAER)将患者则会分为A组(单纯糖尿病组)、B组(合并早期慢性肾病组,UAER大于20μg/min,且小于200μg/min)、C组(合并临床期慢性肾病组,UAER大于200μg/min)。检测患者糖化血红蛋白(Hb A1c)、血尿素氮(BUN)、血肌酐(Scr)、血清尿酸(SUA)、血清甘油三酯(TG)、血清总胆固醇(TC)、肾小球过滤率(GFR)、尿转铁蛋白(TF)以及身体质量指数(BMI),并分析上述指标与糖尿病慢性肾脏疾病的关系。研究显示,TC、TF是与糖尿病慢性肾病关系最为密切的危险因素(p<0.05),且与UAER具有正相关性(p<0.05);TC、TF联合诊断曲线下面积(AUC)为0.96。这提示TC、TF两种指标联合检测可能会提高糖尿病慢性肾病的诊断率。更多还原

【Abstract】 In order to investigate the effect of the common clinical detection indicator on the diagnostic rate of chronic kidney disease in diabetes mellitus, 143 patients with Ⅱ diabetes mellitus were selected in this study.According to urinary albumin excretion rate(UAER), the patients were divided into group A(simple diabetes mellitus group), group B(combined with earlychronic kidneydisease group, UAER>20 μg/min and UAER<200 μg/min)and group C(combined with clinical chronic kidney disease, UAER >200 μg/min). The glycosylated hemoglobin(Hb A1c), blood urea nitrogen(BUN), serum creatinine(Scr), serum uric acid(SUA), serum triglyceride(TG),serum total cholesterol(TC), glomerular filtration rate(GFR), urinary transferrin(TF), and body mass index(BMI)of patients were detected, and their relationship with the indexes of chronic kidney disease and diabetes was analyzed. The results showed that TC and TF were the most closely related risk factors for diabetic chronic nephropathy and had positive correlation with UAER(p<0.05); the area under the combined diagnosis of TC and TF(AUC) was 0.96. This suggested that the combined detection of TC and TF might improve the diagnosis of diabetic chronic nephropathy.更多还原