【摘要】 目的探讨米诺环素联合利培酮对早期精神分裂症患者阴性症状及认知功能的作用及机制。方法早期精神分裂症患者86例随机分为观察组和对照组,各43例,对照组给予利培酮+安慰剂,观察组:米诺环素联合利培酮。两组均治疗16周,比较两组的有效率、阴性症状、认知功能及血清白介素-1β(IL-1β)、肿瘤坏死因子(TNF-α)、脑源性神经营养因子(BDNF),并观察不良反应。结果观察组的治疗有效率(86.0%)高于对照组(67.4%)(P<0.05);治疗后观察组SANS评分均较对照组显著下降(P<0.05),中文版精神分裂症认知功能成套测验(MCCB)评分高于对照组(P<0.05);治疗后观察组血清IL-1β、TNF-α低于对照组,BDNF高于对照组升高(P<0.05);两组不良反应发生率20.9%、18.6%比较无显著差异(P>0.05)。结论米诺环素联合利培酮可有效治疗早期精神分裂症,可能通过降低IL-1β、TNF-α、升高BDNF水平而改善患者阴性症状及认知功能。更多还原

【Abstract】 Objective To explore the effect of minocycline combined with risperidone on negative symptoms and cognitive function in patients with early schizophrenia. Methods Eighty-six patients with early schizophrenia were selected and randomly divided into the observation group and the control group,43 cases in each group. The control group were treated with risperidone and placebo while the observation group were treated with risperidone and minocycline. The duration of treatment was 16 weeks,and the effective rate of treatment,negative symptoms and cognitive function was compared between the two groups. The serum interleukin-1β(IL-1β),tumor necrosis factor α(TNF-α)and brain-derived neurotrophic factor(BDNF)were determined,and the adverse reactions were observed. Results The effective rate of treatment in the observation group(86.0%)was higher than the control group(67.4%)(P<0.05). After treatment,the SANS score in the observation group was significantly lower than the control group while MCCB score was significantly higher than the control group(P<0.05). After treatment,the levels of serum IL-1β and TNF-α in the observation group were lower than those in the control group,while the BDNF level was higher than that in the control group(P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups(20.9% vs 18.6%)(P>0.05). Conclusion Minocycline combined with risperidone can relieve the negative symptoms and improve cognitive function through reducing IL-1β and TNF-α and increase BDNF level.更多还原