【摘要】 目的观察氟西汀联合常规疗法治疗对具有强迫症状精神分裂症患者的有效性与安全性。方法选择2013年1月至2015年12月期间,在我院接受治疗的具有强迫症状精神分裂症患者201例,将入组患者随机分为氟西汀组(102例)与对照组(99例)两组,氟西汀组患者接受氟西汀联合常规治疗,对照组患者仅接受常规治疗,比较两组之间疗效与安全性差异。结果对比对照组,氟西汀组在接受治疗后,耶鲁-布朗评分(Y-BOCS评分)及宽容性评分(TO评分)均明显降低(P<0.05);两组对比,简明精神病量表(BPRS)评分及安全性评价不良反应量表(TESS评分)均无明显差别(P>0.05)。结论氟西汀联合常规治疗可以明显缓解精神分裂症患者强迫症状,改善患者社交信任与宽容程度,具有一定疗效与安全性。更多还原

【Abstract】 Objective To elevate the efficacy and safety of fluoxetine combined with conventional therapy in the schizophrenia patients with obsessive-compulsive symptoms;Methods We chose the 201 cases during January 2013 to December 2015 in our hospital. The patients were randomly divided into the fluoxetine group(102 cases),who received fluoxetine combined with conventional treatment,while the control group(99 cases)only received routine treatment. And then we evaluated the efficacy and the safety after a course of treatment;Results Compared with the control group,after treatment,the Yale Brown obsessive(Y-BCOS)score and tolerance(TO)score of the fluoxetine group were significantly decreased(P<0.05);But there were no significant difference between the two groups(P>0.05)on the scores of Brief Psychiatric Rating Scale(BPRS)and Treatment Emergent Symptom Scale(TESS). ConclusionCombined with the routine therapy,the fluoxetine could improve the obsessive-compulsive symptom in. schizophrenia patients.更多还原