【摘要】 目的探讨成人癫痫共患抑郁患者睡眠障碍的临床特点及其影响因素。方法采取横断面研究方法,对100例癫痫患者应用贝克抑郁量表Ⅱ(BDI-Ⅱ)进行评估。癫痫患者与年龄、性别等严格匹配的50名健康成人均完成匹兹堡睡眠质量量表(PSQI)和Epworth嗜睡量表(ESS)评定。结果 100例成人癫痫患者中30例共患抑郁,共患率为30%。癫痫共患抑郁患者PSQI总分和ESS总分分别为(5.93±1.41)分和(6.57±4.48)分,均高于非抑郁癫痫组分别为(2.09±1.38)分和(3.79±1.98)分及对照组分别为(0.94±0.91)分和(2.30±1.53)分,P<0.05。多元回归分析显示癫痫共患抑郁组的PSQI总分与病程和发作控制相关(t=4.279,2.406;P<0.05);癫痫共患抑郁组的ESS总分与病程和发作类型相关(t=6.662,2.645;P<0.05)。结论成人癫痫共患抑郁患者白天嗜睡程度增加、睡眠质量下降,其损害的严重程度与患者的病程、发作控制和发作类型密切相关。更多还原

【Abstract】 Objective To investigate the clinical features of sleep disorders in adult patients with epilepsy and depression and related influencing factors.Methods A cross-sectional study was performed and Beck Depression Inventory-II( BDI-II) was used for the evaluation of 100 patients with epilepsy. The Pittsburgh Sleep Quality Index( PSQI) and Epworth Somnolence Scale( ESS) were used for evaluating the patients with epilepsy and 50 healthy adults strictly matched for age and sex.Results Of all 100 adults with epilepsy,30 had depression,resulting in a comorbidity rate of 30%. The patients with epilepsy and depression had significantly higher global PSQI and ESS scores than the patients with epilepsy alone and the control group( global PSQI score: 5.93±1.41 vs 2.09±1.38 and 0.94±0.91,P<0.05; global ESS score: 6.57±4.48 vs 3.79±1.98 and 2.30±1.53,P<0.05). The multivariate regression analysis showed that in the patients with epilepsy and depression,global PSQI score was correlated with the course of disease and seizure control( t = 4.279 and 2.406,P<0.05),while global ESS score was correlated with the course of disease and seizure type( t = 6.662 and 2.645,P<0.05).Conclusions Adult patients with epilepsy and depression have an increase in the degree of daytime lethargy and a reduction in sleep quality,and the severity of sleep disorders is closely associated with the course of disease,seizure control,and seizure type.更多还原