Objective Establish an osteoarthritic model in high-fat diet induced obese mice to study obesity-related osteoarthritis(OA). Methods Twenty C57 BL/6 J male mice were randomized into control and high-fat diet groups fed with basic or high-fat diet respectively. Body weight and food intake were measured weekly. Sixteen weeks later serum samples were collected to determine serum collagen typeⅡ C-telopeptide(CTX-Ⅱ) levels by ELISA. Their left knee joints were fixed, decalcified and paraffin embedded for histolo...
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