Objective To explore an improved method of applying four-partition small-aperture embedding boxes(the boxes) in sampling and embedding the pathological specimens of gastrointestinal biopsies for an improvement of the efficiency and quality of slice preparation. Methods In control groups, pieces of gastrointestinal biopsy tissue were randomly placed in the boxes without(control A) or with(control B) record of the number. In the improvement group, the four partitions of the boxes were defined as four quadrant...