【摘要】 目的了解广东省急性乙型病毒性肝炎(乙肝)感染的可能影响因素,为预防控制新发乙肝提供科学依据。方法采用1∶1配对的病例对照研究。选取广东省6个乙肝监测点确诊的新发乙肝患者作为病例,选取同性别、年龄±1岁、HBs Ag和抗-HBs 2项指标同时阴性者作为对照,进行既往肝病史、6个月内输/献血史、医源性接触史、免疫史、生活接触史等问卷调查,对调查结果进行单因素和多因素logistic回归分析。结果 2013年1月至2015年8月广东省6个乙肝监测点共报告确诊急性乙肝病例213例,完成病例对照配对123对,其中男性90对,女性33对;病例组平均年龄为(42.02±18.11)岁,对照组为(42.46±17.98)岁,2组的年龄构成一致(P>0.05)。多因素logistic回归分析显示,乙肝疫苗接种史是急性乙肝感染的保护因素,OR=0.013(95%CI:0.001~0.169);既往肝病史、家庭(宿舍)内有乙肝患者或乙肝病毒携带者、肌肉或静脉注射是急性乙肝感染的危险因素,OR值分别为152.144(95%CI:11.473~2 017.590)、5.182(95%CI:1.073~25.033)和21.097(95%CI:3.407~130.656)。结论接种乙肝疫苗是急性乙肝感染的保护因素,而既往肝病史、家庭(宿舍)内有乙肝患者或乙肝病毒携带者、肌肉或静脉注射是急性乙肝感染的危险因素。建议高危人群尽早接种乙肝疫苗。更多还原

【Abstract】 Objective To understand possible factors influencing infection of acute hepatitis B( AHB) in Guangdong Province so as to provide scientific basis for prevention and control of it. Methods A 1 ∶ 1 matched case-control study was conducted. Patients with newly diagnosed AHB in 6 hepatitis B( HB) surveillance sites in Guangdong Province were selected as the case group and individuals matched by the same gender,age( ± 1 year),and with both negative HBs Ag and anti-HBs were selected as the controls. Participants were asked to complete a questionnaire about their histories of liver disease,blood transfusion / donation within 6 months,iatrogenic exposure,immunization,and life contact. Univariate and multivariate logistic regression models were used to analyze the data. Results From January 2013 to August2015,213 cases of AHB were reported by six surveillance sites in Guangdong Province. A total of 123 cases-control pairs( 90 male pairs and 33 female pairs) were included in the final analysis. The average age was( 42. 02 ± 18. 11) years for the cases and( 42. 46 ± 17. 98) years for the controls. Age structures between the two groups were consistent( P > 0. 05). Multivariate logistic regression showed that history of HB vaccination( OR: 0. 013,95% CI: 0. 001- 0. 169) was a protective factor for AHB,while liver disease history( OR: 152. 144,95% CI: 11. 473- 2 017. 590),patients with HB or HB carriers in the family( dormitory)( OR: 5. 182,95% CI: 1. 073- 25. 033) and muscle / intravenous injection( OR: 21. 097,95% CI:3. 407- 130. 656) were risk factors for AHB. Conclusion HB vaccination was a protective factor for AHB. Liver disease history,HB patients or carriers in the family( dormitory),and muscle / intravenous injection were risk factors. High-risk groups should be vaccinated with HB vaccines as soon as possible.更多还原