【摘要】 提出了一种合成2-羟基-2-(4-氯苯基)-N-(α-甲基苄基)乙酰胺的全新方法,其中酰胺键合成部分采用了活化后带正电性的氨基片段对活化后带负电性的酰基片段进行亲电进攻的极性反转反应机理,该法在合成其他扁桃酰胺类化合物方面具有一定前景。更多还原

【Abstract】 Providing a new synthesis method of 2-(4-chlorophenyl)-2-hydroxy-N-(1-phenylethyl)acetamide, which using nitroalkanes as acyl anion equivalents and the polarities of the two reactants are reversed during carbon–nitrogen bond formation relative to traditional approaches. This provides a conceptually innovative approach to amide.更多还原