【摘要】 血管壁损伤时,血小板聚集形成血栓。血栓形成的数值模拟研究有助于加深对生理过程的了解,为疾病的预防与治疗提供科学依据。血栓形成是一个包涵多相流、颗粒流的复杂问题,MPS方法作为拉格朗日粒子方法具有独特优势。本文提出了一种基于MPS方法的血栓模型,将血小板简化为单个粒子,红细胞由1个核粒子和20个吸附粒子组成以维持圆盘形态,活化血小板与受损血管壁之间的吸附力和聚集力用弹簧模型模拟。本文计算了二维90°Y型分叉管中血栓形成的过程。结果显示血栓形成的位置和大小对红细胞进入两个分叉的比例有密切影响。更多还原

【Abstract】 The pale thrombus due to the vessel injury is composed of aggregated activated platelets.Computational fluid dynamics research is a powerful tool to understand the mechanism of pale thrombus formation, and provide scientific basis for prevention and treatment of the related diseases.The Moving Particle Semi-implicit(MPS) method has great priority for such particle suspension problems due to its Lagrangian nature. A numerical model of the pale thrombus formation based on the MPS method was proposed. A platelet is modeled as a rigid MPS particle, a Red Blood Cell(RBC) is composed of 1 kernel particle and 20 adhesive particles, and the adhesion and aggregation forces between platelets and the injured vessel are simulated by the spring model. The pale thrombus formation problem in 2 D 90° Y-bifurcation vessel is simulated by the present model. The result shows that the position and size of the thrombus have a significant impact on the RBC distribution in two branch vessels.更多还原