【摘要】 目的:探讨乳腺浸润性导管癌(IDC)的预后因素以及PET/CT-SUVmax和DWI-ADC值的关系。方法:搜集经病理证实的36例IDC患者的病例资料,所有患者均行术前MR-DWI、FDG-PET/CT检查及病灶病理检查。病理组织学分析包括肿瘤大小、淋巴结转移、雌激素受体(ER)、孕酮受体(PR)、人上皮生长因子受体(HER2)、Ki-67和人表皮生长因子受体表达水平。分析ADC值、SUVmax与上述预后因素的关系。结果:ADC值在淋巴结转移阳性、ER(+)和HER-2(-)表达的病灶均较高(P<0.01)。肿瘤体积大、淋巴结转移阳性、高级别肿瘤、ER(-)、PR(-)、EGFR(+)和Ki-67高表达者,SUVmax值均较大(P<0.01)。肿瘤ADC值与SUVmax无相关性(P=0.187)。结论:ADC值和SUVmax均具有助于IDC预后的预测。更多还原

【Abstract】 Objective:To discuss the relationship of the prognostic factors with the SUVmax value of PET/CT and ADC values of MR diffusion imaging in patients with invasive ductal carcinoma(IDC)of breast.Methods:The clinical materials of 36 patients with pathology confirmed IDC of breast were reviewed.All patients underwent MR-DWI,FDG-PET/CT and pathology study.Patho-histologic analysis including tumor size,lymph node metastasis,expression of estrogen receptor(ER),progesterone receptor(PR),human epidermal growth factor receptor 2(HER2),Ki-67,and epidermal growth factor receptors(EGFR)were performed.The relationship of ADC value,SUVmax and prognostic factors were studied.Results:ADC value was high in lesions with lymphatic metastasis,ER-positive and HER2-negative expression(P<0.01).In addition,high SUVmax value could be assessed in lesions with large volume,high-grade neoplasm,lymph node metastasis,ER(-)、PR(-)、EGFR(+)and high Ki-67expression(P<0.01).However,there was no significant correlation between ADC value and SUVmax(P=0.187).Conclusion:ADC and SUVmax values were both useful for predicting the prognosis of IDC of breast.更多还原