【摘要】 目的:探讨MR mDixon-Quant技术在精确测量2型糖尿病合并非酒精性脂肪肝患者肝脏脂肪含量中的应用价值。方法:共纳入98例研究对象,其中糖尿病组(患有2型糖尿病)男33例,女16例,对照组(无2型糖尿病)男33例,女16例。所有研究对象均行肝脏3.0T MR mDixon-Quant检查,并测量肝脏脂肪含量(%)。以脂肪含量>5%作为脂肪肝的诊断标准。比较两组非酒精性脂肪肝检出率的差异。结果:糖尿病组肝脏脂肪含量中位数为5.5%(25分位值3.8%,75分位值11.0%),对照组肝脏脂肪含量中位数为3.7%(25分位值2.5%,75分位值5.7%)。糖尿病组脂肪肝总检出率为59.2%,对照组为28.6%。在男性研究对象中,糖尿病组脂肪肝检出率为63.6%(21/33),高于对照组(30.3%,10/33),差异有统计学意义(P<0.05);在女性研究对象中,糖尿病组脂肪肝检出率为50.0%(8/16),高于对照组(25.0%,4/16),但差异无统计学意义(P>0.05)。结论:采用MR mDixon-Quant技术可简便、精确测量2型糖尿病合并非酒精性脂肪肝患者的肝脏脂肪含量,可为疾病的筛查、诊断和治疗效果评估提供重要参考。更多还原

【Abstract】 Objective:To investigate the application value of MR mDIXON-quant technique in accurate quantification of liver fat content in type 2diabetic patients with non-alcoholic fatty liver disease(NAFLD).Methods:98subjects were studied in this research,including 33 males and 16 females in diabetic group,33 males and 16 females in control group(nondiabetic group).All subjects underwent liver MR mDIXON-quant imaging,and liver fat content was measured on MR workstation.The difference of detection rate of non-alcoholic fatty liver was compared between the two groups.Results:The median fat content of liver was 5.5%(first quartile 3.8%,third quartile 11.0%)in diabetic group and 3.7%(first quartile2.5%,third quartile 5.7%)in control group.The total detection rate of fatty liver was 59.2% in diabetic group,and30.3%in control group.In the male subjects,the detection rate of fatty liver in diabetic group(63.6%,21/33)was higher than that in control group(30.3%,10/33),and the difference was statistically significant.In female subjects,the detection rate of fatty liver in diabetic group(50%,8/16)was higher than that in control group(25%,4/16),and the difference was not statistically significant.Conclusion:Quantification of liver fat content by MR mDIXON-quant technique was convenient and accurate,and it may provide important reference for assessment of screening,diagnosis and therapeutic effect of type 2diabetic patients with NAFLD.更多还原