【摘要】 目的探讨腹腔镜袖状胃切除术(LSG)在治疗肥胖症和2型糖尿病中的应用价值。方法回顾性分析2011年1月至2013年12月在桂林医学院附属医院胃肠外科接受LSG治疗的24例肥胖症患者的临床资料。所有患者均签署知情同意书,符合医学伦理学规定。其中男9例,女15例;平均年龄(28±6)岁。患者行LSG治疗。记录术前和术后多个时间点患者的体质量、体质指数(BMI)、多余体质量减少百分比、空腹血糖(FPG)、糖化血红蛋白(Hb A1c)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)和低密度脂蛋白胆固醇(LDL-C)等指标。手术前后临床指标的比较采用t检验。结果术后2年,LSG患者的BMI、FPG、HbA1c、TG、LDL-C分别为(39±11)kg/m~2、(6.5±0.7)mmol/L、(6.0±0.5)%、(1.8±1.0)mmol/L、(2.1±0.7)mmol/L,明显低于术前的(50±11)kg/m~2、(9.2±0.7)mmol/L、(7.9±1.8)%、(2.5±1.0)mmol/L、(2.9±0.9)mmol/L(t=5.976、4.731、15.457、8.327、3.726,P<0.05);2型糖尿病的治疗有效率为100%,高脂血症的治愈率为75%。结论 LSG治疗肥胖症和2型糖尿病的短中期疗效较好,值得在临床上推广使用。更多还原

【Abstract】 Objective To investigate the clinical application value of laparoscopic sleeve gastrectomy(LSG) in treating obesity and type 2 diabetes mellitus. Methods Clinical data of 24 obese patients undergoing LSG in the Affiliated Hospital of Guilin Medical College from January 2011 to December 2013 were retrospectively studied. The informed consents of all patients were obtained and the local ethical committee approval had been received. Among the 24 patients,9 were males and 15 were females with an average age of(28±6) years old. All patients received LSG,and their body weight,body mass index(BMI),percentage of excess body weight loss,fasting plasma glucose(FPG),glycosylated hemoglobin A1c(Hb A1c),triglyceride(TG),high density lipoprotein cholesterol(HDL-C) and low density lipoprotein cholesterol(LDL-C) were collected before and after operation. Comparisons of these data before and after operation were conducted using t test. Results Two years after operation,BMI,FPG,HbA1 c,TG,LDL-C of these patients were(39±11) kg/m~2,(6.5±0.7) mmol/L,(6.0±0.5)%,(1.8±1.0) mmol/L and(2.1±0.7) mmol/L respectively,which were significantly lower than(50±11) kg/m~2,(9.2±0.7) mmol/L,(7.9±1.8)%,(2.5±1.0) mmol/L and(2.9±0.9) mmol/L before operation(t=5.976,4.731,15.457,8.327,3.726,P<0.05); the effective rate of type 2 diabetes mellitus was 100%,and the cure rate of hyperlipemia was 100%. Conclusions LSG has a good short-and mid-term curative effect on obesity and type 2 diabetes mellitus,so it is worthy of clinical promotion and application.更多还原