【摘要】 目的观察分析阿司匹林联合氯吡格雷对急性缺血性脑卒中神经功能及血清C-反应蛋白(CRP)与血脂的影响。方法将2015年2月至2016年2月92例急性缺血性脑卒中患者按照随机数表法分成治疗组(n=46)和对照组(n=46)。对照组应用阿司匹林治疗,治疗组在此基础上联合氯吡格雷治疗。观察并比较两组患者治疗后的神经功能缺损程度、临床治疗效果,治疗前后血脂变化情况及血清CRP变化情况。结果治疗组总有效率(82.61%)与对照组(63.04%)比较差异有统计学意义(P<0.05);治疗后,两组患者神经功能缺损程度评分较治疗前明显改善,且治疗组评分显著低于对照组,差异有统计学意义(P<0.05);治疗组低密度脂蛋白胆固醇(LDL-C)、总胆固醇(TC)及三酰甘油(TG)均明显低于对照组,高密度脂蛋白胆固醇(HDL-C)水平显著高于对照组,差异有统计学意义(P<0.05);两组血清CRP水平较治疗前显著改善,且治疗组改善水平显著优于对照组,差异有统计学意义(P<0.05)。结论阿司匹林联合氯吡格雷对急性缺血性脑卒中患者有较好的治疗效果,还能有效促进患者的神经功能恢复,显著降低血脂水平和血清CRP水平。更多还原

【Abstract】 Objective To observe the effect of aspirin combined with clopidogrel on neurological function,serum C-reactive protein( CRP) and serum lipids in patients with acute ischemic stroke. Methods Ninety-two patients with acute ischemic stroke from February 2015 to February 2016 were researched,according to the random number table method,they were divided into treatment group( n = 46) and control group( n = 46). Patients in control group were treated with aspirin,and patients in treatment group were treated with aspirin and clopidogrel. The clinical treatment effects and neurologic impairment after treatment,and the changes of serum lipid and CRP before and after treatment of the two groups were observed and compared. Results The total efficiency of treatment group( 82. 61%) was better than that in control group( 63. 04%),the difference was significant( P < 0. 05). After treatment,the neurological deficit scores were significantly improved than before treatment,and the score of the treatment group was significantly lower than that of the control group( P < 0. 05). The low density lipoprotein cholesterol( LDL-C),total cholesterol( TC) and triglyceride( TG) in the treatment group were significantly lower than those in the control group,and the level of high-density lipoprotein cholesterol( HDL-C) was significantly higher than that in the control group,the differences were significant( P < 0. 05). After treatment,the serum CRP level of the two groups was significantly improved compared with before treatment,and the improvement level of the treatment group was significantly better than that of the control group( P < 0. 05). Conclusion Aspirin combined with clopidogrel have good therapeutic effect on patients with acute ischemic stroke,which can effectively promote the recovery of neurological function and significantly reduce the levels of blood lipids and serum CRP.更多还原