【摘要】 旨在研究激光结合丹参对Ⅱ型胶原诱导类风湿性关节炎大鼠模型的类风湿性因子、免疫指标、脏器系数及炎症因子的变化情况,为治疗类风湿性关节炎提供参考依据。用鸡Ⅱ型胶原诱导健康雄性Wistar大鼠为类风湿性关节炎大鼠,造模成功后,随机分为5组,于第35天处死大鼠,取大鼠各脏器,称取其湿重并计算脏器系数,检测并比较各处理组大鼠血清中类风湿性因子(RF)、IL-6、IL-1水平及免疫球蛋白水平等。处理组大鼠血清中的免疫指标IgA水平丹参结合激光组高于模型组及其他治疗组(P<0.05),免疫指标IgG和IgM水平丹参结合激光组低于模型组及其他治疗组(P<0.05)。与模型组、空白对照组比较,各处理组大鼠脏器系数含量降低(P<0.05)。各处理组大鼠血清中IL-1、IL-6及RF含量均低于模型组且高于对照组(P<0.05)。可见激光结合丹参对Ⅱ型胶原诱导类风湿性关节炎大鼠模型具有一定程度的治疗效果。更多还原

【Abstract】 To study the changes of organ coefficient,immune indices and inflammatory factors in the model of collagen induced rheumatoid arthritis in rats by Salvia miltiorrhiza combined with laser for providing a new therapy for the treatment of rheumatoid arthritis,the rats were injected with the chicken collagen of typeⅡfor inducing rats rheumatoid arthritis model,and then divided randomly into 5 groups.The changes of organ coefficients,immune indices,rheumatoid factor and inflammatory factors(IL-6,IL-1)were measured.IgA level in serum of rat group with Salvia miltiorrhiza plus laser was higher than that in the model group and other treatment groups(P<0.05),IgG and IgM levels of Salvia miltiorrhiza combined with laser group was lower than that of model group and other treatment groups(P<0.05).Compared with the model group and the blank control group,the organ coefficients of the rats in each treatment group decreased(P<0.05).The contents of IL-1,IL-6 and RF in serum of treatment group were lower than that in model group,and higher than that in control group(P<0.05).It can be seen that Salvia miltiorrhiza combined with laser has a certain degree of therapeutic effect on type II collagen induced rheumatoid arthritis rat model.更多还原