Objective To explore whether angiotensin-(1-7) [Ang-(1-7)] protects cardiac myocytes against high glucose(HG)-induced injury by inhibiting ClC-3 chloride channels. Method H9c2 cardiac cells were exposed to 35 mmol/L glucose for 24 h to establish a cell injury model. The cells were treated with Ang-(1-7) or the inhibitor of chloride channel(NPPB) in the presence of HG for 24 h to observe the changes in HG-induced cell injury. Cell counter kit 8(CCK-8) assay was used to test the cell viability, and the morpho...
510515;中山大学3附属第一医院黄埔院区儿科,4附属第一医院黄埔院区内科,5中山医学院生理学教研室,广东广州510080;6广东省人民医院//广东省医学科学院//广东省老年医学研究所东病区内分泌科,广东广州510080Angiotensin-(1-7)protects cardiac myocytes against high glucose-i
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