Objective To investigate the effects of prophylactic administration of all- trans retinoic acid(ATRA) in relieving inflammation in a rat model of collagen-induced arthritis(CIA). Methods Female Wistar rats(6 to 8 weeks old) were randomly divided into normal control group, solvent control group, and prophylactic ATRA treatment(0.05, 0.5, and 5 mg/kg) groups.All the rats except for those in normal control group were subjected to subcutaneous injection of type II collagen and incomplete Freund adjuvant in the ...
【基金】
国家自然科学基金(81372983)~~
【更新日期】
2017-02-09
【分类号】
R593.22;R-332
【正文快照】
类风湿关节炎(Rheumatoid arthritis,RA)是一种以关节滑膜炎性病变为主要特征的慢性自身免疫性疾病,主要表现为滑膜炎症及增生、自身抗体的产生、软骨及骨的破坏,严重者关节功能丧失,甚至畸形、伤残[1-2]。Prophylactic administration of all-trans retinoic acid alleviates
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