【摘要】 目的补充维生素D₃在儿童哮喘控制中的应用效果为预防儿童哮喘的复发提供科学依据。方法采用双盲法随机对照设计原则,将2015年1月至2015年12月在该院门诊随访的儿童哮喘患者（92例）分为维生素D组和安慰剂组,两组分别服用剂量为800IU每天1粒2个月疗程的维生素D₃和安慰剂。研究两组在基线,2、6个月哮喘控制水平得分,血清25羟基维生素D₃水平和肺功能指标。结果共有83例完成整个随访,其中维生素D组43例,安慰剂组40例。在2个月后,维生素D组的哮喘控制水平明显高于安慰剂组（P=0.015）,同样血清25羟维生素D₃水平亦高于安慰剂组（P=0.042）,两组肺功能差异无统计学意义（P>0.05）;6个月后维生素D组的哮喘控制水平仍高于安慰剂组,但差异无统计学意义（P=0.094）,两组血清25羟维生素D₃水平差异无统计学意义（P>0.05）,而维生素D组中小于80%的呼气峰流速占预计值百分比（PEF%）比例降低（P=0.029）。结论短期小剂量的维生素D补充能够在一定程度上提升哮喘控制水平,有积极的临床应用价值。更多还原

【Abstract】 Objective To explore the effect of vitamin D₃ supplementation on childhood asthma control for the purpose of providing a scientific basis for preventing the recurrence of childhood asthma.Methods A total of 92 children with asthma enrolled from January 2015 to December 2015 was divided into vitamin D group and placebo group by adopting double-blind randomized controlled design principles.Two groups were given a dose of 800 IU of vitamin D₃ and placebo respectively,1 tablet per day for 2 months of treatment.The levels of asthma control and serum 25-hydroxy vitamin D₃ and lung function index were examined at baseline,2 months and 6 months.Results A total of 83 patients completed the entire follow-up,including 43 patients in the vitamin D group and 40 patients in the placebo group.After 2 months,the level of asthma control in the vitamin D group was significantly higher than that in the placebo group（P=0.015）and the level of serum 25-hydroxy vitamin D₃ was also higher in the vitamin D group than in the placebo group（P=0.042）.There was no significant difference of pulmonary function index between the two groups（P>0.05）.After 6 months,the level of asthma control in the vitamin D group was still higher than that in the placebo group with no significant difference（P=0.094）.There was no significant difference in the level of serum 25-hydroxy vitamin D₃ between the two groups.The percentage of the less than 80% peak expiratory flow rate（PEF%）was significantly decreased in the vitamin D group（P=0.029）.Conclusion Short-term low-dose vitamin D supplement can enhance the level of asthma control and has positive clinical application value.更多还原