【摘要】 目的分析养阴消瘿方联合西药治疗Graves病患者的临床疗效及其作用机制。方法选择2012年1月至2014年12月于该院内分泌门诊初次就诊的Graves病患者50例,采用随机数字表法将患者分为观察组和对照组,各25例。另选取同期行健康查体者25例作为健康对照组。对照组给予甲巯咪唑、普萘洛尔等西药治疗,观察组在西药基础上给予养阴消瘿方治疗,均治疗2个月。观察3组治疗前后血清游离三碘甲状腺原氨酸(FT3)、血清游离甲状腺素(FT4)、促甲状腺激素(TSH)、甲状腺球蛋白抗体(TGAb)、甲状腺过氧化物酶抗体(TPOAb)水平,辅助性T淋巴细胞(Th)1、Th2、Th17占CD4+细胞的百分比及其相对应的细胞因子水平。结果观察组与对照组患者治疗后FT3、FT4、TGAb及TPOAb水平较治疗前均明显下降,TSH水平明显上升(P<0.05),两组患者Th1、Th2及Th17细胞百分比均较治疗前明显降低(P<0.05)。观察组与对照组患者治疗后干扰素-γ(IFN-γ)、白细胞介素(IL)-4水平、IFN-γ/IL-4比值及IL-12、IL-5水平、IL-12/IL-5比值较治疗前均明显下降(P<0.05)。观察组与对照组患者治疗后IL-17A、IL-17F、IL-23水平较治疗前明显降低(P<0.05)。并且治疗后观察组上述各项指标均优于对照组(P<0.05)。结论养阴消瘿方联合西药治疗Graves病的临床疗效确切,可明显改善患者的甲状腺功能。更多还原

【Abstract】 Objective To investigate the clinical efficacy and its mechanism of Yangyin Xiaoying decoction combined with western medicine in the treatment of Graves′Disease.Methods A total of 50 patients suffered from Graves′Disease in our hospital were selected from January 2012 to December 2014,and were randomly divided into observation group and control group using random number table method,25 cases in each group.Other 25 cases of healthy subjects were selected in the same period in our hospital as the healthy control group.The control group received the treatment of methimazole,propranolol and other western medicine.The observation group received Yangyin Xiaoying decoction combined with western medicine.After 2 months of treatment,the levels of free triiodothyronine(FT3),free thyroxine(FT4),thyroid stimulating hormone(TSH),thyroglobulin antibody(TGAb)and thyroid peroxidase(TPOAb),and the percentages of Th1,Th2,Th17 cells in CD4+cells and their corresponding cytokine levels were detected.Results After treatment,the levels of FT3,FT4,TGAb and TPOAb in the observation group and control group were significantly decreased,and levels of TSH were significantly increased in the two groups(P<0.05);percentages of Th1,Th2 and Th17 cells in the observation group and control group were significantly lower than those before treatment(P<0.05).After treatment,the interferon-γ(IFN-γ),interleukin(IL)-4 levels and IFN-γ/IL-4 ratio,IL-12,IL-5 levels and IL-12/IL-5 ratio in the observation group and control group were significantly lower than those before treatment(P<0.05).The IL-17 A,IL-17 Fand IL-23 levels in the observation group and control group after treatment were significantly decreased,compared with those before treatment(P<0.05).The degree of improvement of above indexes in the observation group were better than those in the control group(P<0.05).Conclusion Yangyin Xiaoying decoction combined with western medicine can significantly improve patients′thyroid function,which suggests that it may have a role in the therapy in the treatment of Graves′disease.更多还原