Objective To investigate the correlation between autophagy related gene(ATG)locus polymorphism and the pulmonary tuberculosis(PTB)susceptibility according to the frequency distribution characteristics of autophagy related gene in the patients with PTB.Methods Eighteen single nucleotide polymorphism(SNP)loci of autophagy related genes in 202 patients with PTB as the case group and 222 healthy controls were genotyped by SequenomMassArray mass spectrometry array technology.The correlation between the each locu...
【基金】
国家自然科学基金资助项目(81171628);
重庆市卫计委基金资助项目(2012-2-370)
【更新日期】
2017-09-06
【分类号】
R521
【正文快照】
肺结核是由结核分枝杆菌持续感染导致的慢性传染病,机体发病与否主要取决于宿主、自然环境和菌株三因素。近来众多研究表明,基因多态性可能影响肺结核的患病风险,暗示个体遗传因素与结核病的发生与发展密切相关[1]。本课题组前期研究证实自噬相关基因(autophagy associated gen