【摘要】 目的探讨血清正五聚蛋白(PTX)3水平在2型糖尿病(T2DM)患者不同体质量指数(BMI)组中的变化及与代谢指标的相关性。方法 164例T2DM患者根据BMI分为体质量正常组(A组)53例、超重组(B组)56例及肥胖组(C组)55例,采用酶联免疫法测定各组血清PTX3水平,分析血清PTX3水平与BMI、血糖、血脂、胰岛素抵抗指数(HOMA-IR)等的关系。结果血清PTX3水平在A、B、C组分别为(3.46±0.19)、(2.47±0.21)、(1.44±0.18)ng/mL,组间两两比较,差异有统计学意义(P<0.05)。PTX3水平与BMI、TG、LDL-C、空腹胰岛素(Fins)、HOMA-IR负相关(r分别为-0.897、-0.621、-0.232、-0.593、-0.487,P<0.01或P<0.05),多元逐步回归分析显示,BMI、HOMA-IR与PTX 3水平独立相关。结论 T2DM患者中,BMI、HOMA-IR是影响血清PTX 3水平降低的独立危险因素。更多还原

【Abstract】 Objective To investigate the change of serum pentraxin3 level in different body mass indices groups among the patients with type 2diabetes mellitus(T2DM)and to analyze its correlation with metabolic indices.Methods A total of 164T2 DM patients were divided into the normal body mass group(A,n=53),over-weight group(B,n=56)and obese group(C,n=55)according to BMI.Serum pentraxin3 level was assayed by ELISA.Then the relationship between serum pentraxin3 levels with BMI,blood glucose,blood lipid andHOMA-IR was analyzed.Results The pentraxin3 levels in the group A,B and C were(3.46±0.19),(2.47±0.21),(1.44±0.18)ng/mL respectively,the pairwise comparison among three groups showed the statistical difference(P<0.05).The pentraxin3 level was negatively correlated with BMI,TG,LDL-C,FINS and HOMA-IR(r=-0.897,-0.621,-0.232,-0.593,-0.487,P<0.05 or P<0.01).The multiple stepwise regression analysis showed that BMI and HOMA-IR were independently correlated with serum pentraxin3 level.Conclusion BMI and HOMA-IR are the independent risk factor for affecting serum pentraxin3 level in T2 DM patients.更多还原