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高龄不孕症患者经自然周期排卵后继续黄体期促排的可行性分析

Analysis on feasibility of promoting ovulation during continuous luteal phase after natural cycle ovulation in senile infertility patients

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【作者】 张明哲彭先敏叶贵丹

【Author】 Zhang Mingzhe;Peng Xianmin;Ye Guidan;Center of Reproductive Medicine,Affiliated Hospital,Zunyi Medical College;Center of Reproductive Medicine,Affiliated Hospital of Guizhou Medical University;

【机构】 遵义医学院附属医院生殖中心贵州医科大学附属医院生殖中心

【摘要】 目的对高龄患者经自然周期促排卵后继续黄体期促排的结果进行可行性分析。方法收集在该院生殖中心进行体外受精-胚胎移植技术(IVF-ET)助孕的夫妇资料,分别采用经自然周期排卵后继续黄体期促排方案和常规方案,统计分析对照组和试验组基本资料和实验室各指标的差异。结果两组的周期数、年龄、不孕年限、基础小卵泡数、基础卵泡雌激素及基础雌二醇比较差异均无统计学意义(P>0.05);对照组的获卵数、成熟卵子数、第3天优质胚胎数、成囊率、冷冻胚胎数低于试验组,差异具有统计学意义(P<0.05);对照组的两原核受精率略高于试验组,但二者之间差异无统计学意义(P>0.05)。结论自然周期排卵后继续黄体期促排方案可提高高龄患者胚胎的数量和质量。

【Abstract】 Objective To analyze the feasibility of promoting ovulation during continuous luteal phase after natural cycle ovulation in senile infertility patients.Methods The data of couples of in vitro fertilization-embryo transplantation(IVF-ET)assisted pregnancy in the reproductive center of our hospital were collected.They respectively adopted the promoting ovulation scheme during continuous luteal phase after natural cycle ovulation and conventional scheme.The differences in the basic data and laboratory indexes in the control group and experimental group were statistically analyzed.Results The number of cycles,age,infertility years,number of basic small follicles,basic FSH and E2 had no statistically significant differences(P>0.05);the retrieved oocyte number(D3),matured egg(MⅡ)number,high quality embryo number on 3d(D3),forming cyst rate and frozen embryo number in the control group were significantly lower than those in the experimental group,the differences were statistically significant(P<0.05),but the two prokaryotic(2PN)fertilization rate in the control group was slightly higher than that in the experimental group,but the difference between them had no statistical significance(P>0.05).Conclusion The promoting ovulation scheme during continuous luteal phase after natural cycle ovulation can improve the number and quality of embryos in senile patients.

【基金】 贵州省科学技术基金(黔科合J字2012-2363号)
  • 【文献出处】 重庆医学 ,Chongqing Medicine , 编辑部邮箱 ,2017年02期
  • 【分类号】R711.6
  • 【被引频次】8
  • 【下载频次】309
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