【摘要】 目的探讨联合检测血脂、血糖及肝功能对脂肪肝患者的诊断和治疗的临床意义。方法回顾性分析2016年7月至2017年7月山东省临沭县人民医院收治的80例脂肪肝患者(脂肪肝组)及80例健康体检人员(健康体检组)的临床资料,比较两组血脂、血糖及肝功能指标的检测结果。结果与健康体检组比较,脂肪肝组三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、空腹血糖(FBG)、丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)和γ-谷氨酰转肽酶(GGT)水平均明显升高,高密度脂蛋白胆固醇(HDL-C)明显降低(均P<0.05)。健康体检组、轻度脂肪肝组、中度脂肪肝组、重度脂肪肝组的血脂、血糖升高程度和肝功能降低程度逐渐加重[TG(mmol/L):1.4±0.3、1.9±0.3、3.1±0.8、4.1±0.4;TC(mmol/L):3.8±0.9、4.6±0.6、5.2±0.7、6.1±0.5;LDL-C(mmol/L):2.4±0.3、2.8±0.6、3.5±0.5、4.4±0.6;HDL-C(mmol/L):1.7±0.2、1.3±0.5、0.7±0.2、0.4±0.1;FBG(mmol/L):4.9±1.3、6.3±1.1、7.1±0.2、8.6±1.3;ALT(U/L):25.5±4.6、31.2±5.9、39.1±6.4、46.8±5.9;AST(U/L):24.9±4.8、32.8±6.4、39.8±5.9、46.9±6.2;GGT(U/L):29.5±5.7、40.5±6.8、49.9±5.4、59.6±6.5],各组间比较差异均有统计学意义(均P<0.05)。结论联合检测血脂、血糖及肝功能,对脂肪肝患者诊断和治疗的临床意义显著。更多还原

【Abstract】 Objective To investigate the clinical significance of combined detection of serum lipid,glucose and liver function in the diagnosis and treatment of patients with fatty liver.Methods The clinical data from fatty liver patients(fatty liver group,n = 80) and health checkups(control group,n = 80) from July 2016 to July 2017 in Shandong Linshu People’s Hospital were retrospectively analyzed.By comparing the two groups of blood lipid,blood glucose and liver function test results between the two groups.Results The values of serum triglyceride(TG),total cholesterol(TC),low density lipoprotein cholesterol(LDL-C),fasting blood glucose(FBG),alanine aminotransferase(ALT),aspartate aminotransferase(AST) and gamma glutamyl transpeptidase(GGT) in fatty liver patients were significantly higher than those in checkups(all P < 0.05),however the measures of high-density lipoprotein cholesterol(HDL-C) in patients with fatty liver decreased significantly(P < 0.05).The elevation tendency of serum lipid,blood glucose and liver function gradually increased in the checkups and the subgroups of mild fatty liver,moderate fatty liver,and severe fatty liver respectively [TG(mmol/L):1.4±0.3,1.9±0.3,3.1±0.8,4.1±0.4;TC(mmol/L):3.8±0.9,4.6±0.6,5.2±0.7,6.1±0.5;LDL-C(mmol/L):2.4±0.3,2.8±0.6,3.5±0.5,4.4±0.6;HDL-C(mmol/L):1.7±0.2,1.3±0.5,0.7±0.2,0.4±0.1;FBG(mmol/L):4.9±1.3,6.3±1.1,7.1±0.2,8.6±1.3;ALT(U/L):25.5±4.6,31.2±5.9,39.1±6.4,46.8±5.9;AST(U/L):24.9±4.8,32.8±6.4,39.8±5.9,46.9±6.2;GGT(U/L):29.5±5.7,40.5±6.8,49.9±5.4,59.6±6.5],with statistically significant differences among all the groups(all P < 0.05).Conclusion It is of great importance in diagnosing and treating of patients with fatty liver by using the method of joint detection of serum lipid,glucose,and liver function.更多还原