An autopsy was made on a case of endemic cretinism.On microscopic changeshis central nervous system and endocrine organs were observed.1.The weight and size of the brain were below normal.The cerebral ventric-le was slightly dilated.The size of nerve cell was smaller and Nissl's bodies incytoplasm disappeared.The myelin sheath(Weil's staining method)looked evidentlysparse.2.Anterior pituitary showed marked hypertrophy.Basophilic cells hyperpla-sia was found.The plasma of these cells was filled with dense re...