【摘要】 目的:观察利拉鲁肽对初诊肥胖2型糖尿病患者腰围和胰岛功能的影响。方法:选取体重指数(body mass index,BMI)≥28 kg/m~2初诊2型糖尿病患者38例,应用利拉鲁肽注射液治疗24周,比较治疗前后患者的空腹血糖(fasting blood glucose,FBG),餐后2 h血糖(2 h blood glucose,2h PG)、糖化血红蛋白(hemoglobin a1c,Hb Alc)、甘油三酯(triacylglyceride,TG)、低密度脂蛋白(low density lipoprotein cholesterol,L-DLC)、BMI、腰围(waist circumference,WC)、空腹胰岛素(fasting insulin,FIns)、胰岛素抵抗指数(homeostasis model assessment-insulin resistance index,HOMA-IR)、胰岛素敏感指数(homeostasis model assessment index ofβcell,HOMA-β)。结果:与治疗前比较,患者的FBG、Hb A1c、TG、BMI、HOMA-IR均下降(P<0.05)。治疗后的HOMA-β与治疗前相比升高(P<0.05)。结论:对初诊肥胖的2型糖尿病患者,利拉鲁肽能够有效控制血糖、减小腰围、减轻胰岛素抵抗、提高胰岛素敏感性、改善胰岛β细胞功能。更多还原

【Abstract】 Objective: To investigate the effects of Liraglutide on waist circumference and pancreatic islet function in the overweight or obese patients newly diagnosed with type 2 diabetes. Methods: 38 cases of overweight or obese patients newly diagnosed with type 2 diabetes( body mass index≥28kg/m~2) were selected as subjects and treated with Liraglutide injection for 24 weeks. Levels of their fasting blood glucose( FBG),2h postprandial glucose( 2h PG),hemoglobin A1c( HbA1c),triglyceride( TG),low density lipoprotein cholesterol( L-DLC),body mass index( BMI),waist circumference( WC),fasting insulin levels( Fins),homeostasis model assessment of insulin resistance index( HOMA-IR) and homeostasis model assessment of β-cells( HOMA-β) before and after the treatment of Liraglutide were determined and compared. Results: The levels of FBG,Hb A1 c,TG,BMI and HOMA-IR decreased significantly compared with those before the treatment( P < 0. 05),while the level of HOMA-β increased significantly( P < 0. 05). Conclusion: For the obese patients newly diagnosed with type 2 diabetes,Liraglutide can effectively control the blood glucose levels and waist circumference,reduce the insulin resistance and improve the insulin sensitivity,therefore ameliorate the function of islet β cells.更多还原