【摘要】 目的对各类产生蛋白凝集的患者血样进行调查研究,为临床解决蛋白凝集造成的检测困难提供帮助。方法对2006-2015年本实验室84例蛋白凝集案例进行总结,分析血清学试验结果,包括盐水置换试验及显微镜观察影像。结果临床上导致蛋白凝集的疾病主要是多发性骨髓瘤,绝对数(占41%);又以30岁以上的男性居多,男性绝对数(占67%),30岁以上患者绝对数(占99%)。蛋白凝集主要以团块状为主,绝对数(占62.5%),凝集强度主要低于1+。结论蛋白凝集最常见于多发性骨髓瘤,但与多种疾病可能存在关联性,蛋白凝集之间也存在凝集形态上的明显差异。通过显微镜观察,血清或血浆中加入盐水后反应以及结合临床诊断的方法,可有效解决蛋白凝集造成的临床检测困难。更多还原

【Abstract】 Objective To investigate the blood samples from patients who have protein agglutination in order to provide data support to solve clinical problems caused by protein agglutination. Methods A total of 84 cases of protein agglutination in this laboratory from 2006 to 2015 were reviewed,and the results of serological experiments were analyzed,including saline replacement experiment and microscopic observation. Results The major cause of protein agglutination is multiple myeloma,accounting for 41% of the total cases. Most were men over 30 years of age,men accounted for 67% of the total. Patient over the age of 30 accounted for 99% of the total. Protein agglutination formation was mainly in lumps-based shapes,accounting for 62. 5% of the total. Most of the aggregation strength were below 1 +. Conclusion Protein agglutination is most common in multiple myeloma,but may be associated with a variety of diseases,there is also significant differences in formation between different protein agglutination. Through microscopic observation,adding saline to serum or plasma samples,combined with clinical diagnosis,can effectively solve clinical problems caused by protein agglutination.更多还原