【摘要】 目的探讨不同乙型肝炎病毒DNA(HBV-DNA)载量乙型肝炎肝硬化患者血小板参数及D-D变化情况。方法以2015年1月至2016年12月间我院收治的乙型肝炎肝硬化患者60例作为研究对象,所有患者均进行HBV-DNA病毒载量检测、血小板参数检测以及D-二聚体(D-D)检测。将乙型肝炎肝硬化患者按照HBV-DNA载量数量级进行分组,对各组间血小板参数及D-D表达水平进行比较。另收取同期于我院进行常规体检的健康人25例作为对照组。结果乙型肝炎肝硬化患者血小板计数(PLT)、血小板比容(PCT)、明显低于对照组,平均血小板体积(MPV)、血小板分布宽度(PDW)及D-D明显高于对照组;检测下限组、低载量、中载量及高载量组患者之间血小板参数及D-D均存在显著差异(P<0.05),并且下限组、低载量、中载量及高载量组患者的PLT和PCT依次逐渐减小,MPV、PDW及D-D依次逐渐增大。结论乙型肝炎肝硬化高HBV-DNA载量患者存在明显凝血纤溶功能失衡,提示应对患者进行早期抗病毒干预,以减少病毒复制,维持凝血纤溶平衡。更多还原

【Abstract】 Objective Discussing the change of platelet parameters and D-D detection in hepatitis B and liver cirrhosis patients with different HBV-DNA loads. Methods Hepatitis B and liver cirrhosis patients( 60 cases)were selected from January 2015 to December 2016. HBV-DNA loads,platelet parameters and D-dimer( D-D) of all patients were detected. The hepatitis B and liver cirrhosis patients were grouped according with the rank of HBV-DNA loads. Platelet parameters and the expression level of D-D were compared between each group. Healthy people( 25 cases) with regular physical examination were set as control group. Results The platelet count( PLT) and platelet volume( PCT) of hepatitis B and liver cirrhosis patients were significantly lower than that of control group( P < 0. 05); The mean platelet volume( MPV),platelet distribution width( PDW) and D-D of hepatitis B and liver cirrhosis patients were significantly higher than that of control group( P < 0. 05); The platelet parameters and D-D of lowdetection limit,lowloads,intermediate loads and high loads groups had significant different from each others( P < 0. 05); The PLT and PCT of lowdetection limit, lowloads, intermediate loads and high loads groups gradually decreased accordingly,while MPV,PDW and D-D increased gradually. Conclusion Hepatitis B and liver cirrhosis patients with high HBV-DNA loads showobvious blood coagulation fibrinolytic function imbalance and they should be given early antiviral intervention to reduce viral replication and maintain blood coagulation fibrinolytic balance.更多还原