【摘要】 目的:探讨帕金森病(PD)病人血清中分化型胚胎软骨表达基因1(DEC1)和肝X受体β(LXRβ)水平及二者相关性。方法:选择PD病人50例(PD组),选择同期健康人群50名为对照(对照组)。检测2组受试者血清DEC1、LXRβ水平。结果:PD组血清DEC1水平明显高于对照组(P<0.01),LXRβ水平明显低于对照组(P<0.01)。不同性别的PD病人DEC1和LXRβ水平差异均无统计学意义(P>0.05);年龄≥60岁PD病人的LXRβ水平低于<60岁者(P<0.05);有认知功能障碍的PD病人DEC1和LXRβ水平分别明显高于和低于无认知障碍者(P<0.01);随病情分期加重,PD病人的DEC1水平逐渐升高,LXRβ水平逐渐降低(P<0.05~P<0.01)。PD病人血清DEC1水平与LXRβ水平呈负相关关系(r=-0.326,P<0.05)。结论:PD病人血清DEC1与LXRβ水平呈负相关关系,二者与PD的发病及病情进展有关。更多还原

【Abstract】 Objective: To explore the serum levels of differentiated embryonic chondrocyte expression gene 1( DEC1) and liver X receptor β( LXRβ) in Parkinson’ s disease( PD),and its correlation. Methods: Fifty PD patients and 50 healthy people were divided into the PD group and control group,respectively. The serum levels of DEC1 and LXRβ in two groups were tested. Results: The serum levels of DEC1 and LXRβ in PD group were significantly higher and lower than that in control group,respectively( P < 0. 01). The differences of serum levels of DEC1 and LXRβ between different genders of PD group were not statistically significant( P > 0. 05). The serum level of LXRβ in more than or equal to 60 years old PD patients was lower than that in less than 60 years old PD patients( P <0. 05). The serum levels of DEC1 and LXRβ in PD patients with cognitive dysfunction were significantly higher and lower than those in PD patients without cognitive dysfunction,respectively( P < 0. 01). With the deterioration of PD patients,the serum levels of DEC1 and LXRβ gradually increased and decreased,respectively( P < 0. 05 to P < 0. 01). The serum level of DEC1 was negatively correlated with the level of LXRβ in PD patients( r =-0. 326,P < 0. 05). Conclusions: The serum level of DEC1 is negatively correlated with the level of LXRβ in PD patients,which may be involved in the onset and progression of PD.更多还原