【摘要】 目的探讨内镜黏膜下剥离术(ESD)与传统外科手术治疗早期胃癌患者的临床疗效。方法选取148例早期胃癌患者的临床资料进行回顾性分析,根据手术方式的不同将患者分为ESD组(n=69)和传统组(n=79),ESD组患者接受ESD治疗,传统组患者接受传统外科手术治疗,比较两组患者的术中指标、住院情况、并发症发生率及远期预后情况。结果 ESD组患者的手术时间、胃肠减压时间、禁食禁水时间、住院时间明显短于传统组,住院总费用明显低于传统组,差异均有统计学意义(P<0.01)。ESD组患者的并发症发生率为10.14%,低于传统组的24.05%,差异有统计学意义(P<0.05)。ESD组患者的1、2、3年生存率分别为100.00%、96.92%、92.31%,传统组患者的1、2、3年生存率分别为100.00%、98.63%、95.89%,两组患者的生存率比较,差异无统计学意义(P>0.05)。结论 ESD与传统外科手术治疗早期胃癌效果相当,但具有并发症少、手术创伤小、术后恢复快等优势,值得临床推广应用。更多还原

【Abstract】 Objective To evaluate the difference of surgical outcome between endoscopic submucosal dissection(ESD) and conventional surgery in patients with early gastric cancer(EGC). Method 148 EGC patients were reviewed retrospectively, ESD(n=69) or conventional surgery(n=79) were administered for these patients, the intra-operative measures, hospitalization indexes, and long-term complications as well as the long-term prognosis of the two groups were compared. Result The operative time, gastrointestinal decompression time, fasting time and hospital stay were shorter in ESD group compared with conventional surgery group, and the total hospitalization expenses were also less in ESD group(P<0.01); patients in ESD group had an overall incidence of complications of 10.14%, and was lower than that of the conventional surgery group at 24.05%, with significant differences observed(P<0.05); in ESD group, the 1-, 2-, and 3-year survival rate was 100.00%, 96.92% and 92.31%, and these in the traditional group was 100.00%, 98.63% and 95.89%, respectively, with no significant differences observed(P>0.05). Conclusion ESD is similar with conventional surgery for in treatment of EGC patients, with less complications, minimal surgical damage and faster postoperative recovery, and is worthy of clinical promotion.更多还原