【摘要】 目的分析Ⅲa期肺鳞癌的治疗模式。方法回顾性分析102例Ⅲa期肺鳞癌患者的病历资料,并对临床信息及治疗情况等因素对患者生存的影响进行分析。结果 102例Ⅲa期肺鳞癌患者中,行根治性手术患者65例（63.7%）,非根治性手术患者37例（36.3%）。根治性手术组与非根治性手术组患者的中位OS分别为27.9个月和19.0个月,差异有统计学意义（P=0.005）。单因素分析结果显示:N₂淋巴结转移个数和N₂淋巴结转移组数对行根治性手术的Ⅲa/N₂期肺鳞癌患者的OS有影响（P﹤0.05）,而N₂淋巴结转移个数≥3个的患者术后死亡风险更高（RR=3.342）。结论对于Ⅲa期肺鳞癌患者,如果患者体力情况较好,建议行手术治疗。纵隔N₂淋巴结转移个数是影响患者术后生存率的主要因素。更多还原

【Abstract】 Objective To analyze therapy strategies for patients with stage Ⅲa squamous cell lung cancer. Method The medical records of 102 patients with stage Ⅲa squamous cell lung cancer were retrospectively analyzed, and the influences of factors such as clinical information and treatment strategy on the survival of patients were evaluated. Result Of the 102 cases of patients with stage Ⅲa squamous cell lung cancer,65 case（63.7%） had radical surgery and 37（36.3%） had nonradical surgery. The median OS of radical group and non-radical group was 27.9 and 19.0 months respectively,with the difference between two groups being statistically significant（P=0.005）. Univariate analysis indicated that the number of metastatic N₂ lymph nodes and the number of metastatic N₂ lymph node groups had an influence on OS of patients with stage Ⅲa/N₂ squamous cell lung cancer who had undergone radical surgery（P<0.05）, and the risk of death postoperatively in patients with the number of metastatic N₂ lymph nodes≥3 were increased（RR=3.342）. Conclusion For patients with stage Ⅲa squamous cell lung cancer, if their physical condition is satisfactory, surgical treatment is recommended. The number of metastatic mediastinal N₂ lymph nodes is main factors influencing survival postoperatively.更多还原