To investigate the protective mechanism of V. coloratum fruit polysaccharides(VCFP) on acute alcoholic liver injury in mice, an acute liver injury model was established by one time irrigation stomac. The mice were randomly divided into VCFP-treated groups(low-, medium-, and high-dosage), alcohol model group and normal control group at the same time. VCFP-treated group was given polysaccharide on continuous 28 days by gavage; the alcohol model group and normal control group were injected with the same amount...