Compare the hypotension prevention effect of different 5-HT_3 receptor antagonist in fetal and maternal during cesarean delivery with spinal anesthesia
目的比较脊柱麻醉前静注不同5-羟色胺3(5-HT_3)受体拮抗剂预防脊柱麻醉下剖宫产术中低血压的效果以及对产妇和胎儿的影响。方法拟择期在脊柱麻醉下行剖宫产术的单胎足月妊娠产妇120例,按随机数字表法分为S组、T组、G组、A组,每组30例,分别在脊柱麻醉前5 min静脉推注生理盐水5 m L(S组),托烷司琼5 mg(T组)、格拉司琼3 mg(G组)、阿扎司琼10 mg(A组)(所有药物使用生理盐水稀释至5 m L)。从脊柱麻醉鞘内注药2 min后开始,每隔2 min测量并记录一次血压、心率和血氧饱和度(SpO_2)直至鞘内注药30 min。胎儿娩出后即刻取胎儿脐动脉和脐静脉的血标本行血气分析。结果 G组产妇术中低血压和恶心的发生率明显低于S组(P<0.05),G组脐静脉血的二氧化碳分压[p(CO_2)]明显低于S组(P<0.05),T组和A组的恶心发生率明显低于S组(P<0.05)。G组和A组脐静脉血的pH值明显高于S组而碳酸氢根离子(HCO-3)浓度明显低于S组(P<0.05),T组的HCO_3~-浓度也明显低于S组(P<0.05)。G组产妇术中收缩压最大下降值明显小于S组(P<0.05)。结论脊柱麻醉前静...
【英文摘要】
Objective To compare the hypotension prevention effects of different 5-HT_3 receptor antagonist on the fetal and maternal prophylactic intravenous during cesarean delivery with spinal anesthesia. Methods One hundred and twenty mature pregnant women with single-embryo scheduled for elective cesarean section were randomly divided into four groups(Group S,T,G and A,n = 30). Five minutes prior to spinal anesthesia,women were injected IV saline 5 m L(S),tropisetron 5 mg(T),granisetron 3 mg(G),azasetron 10mg(A)(t...
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