【摘要】 目的探讨利用动脉质子自旋标记成像(ASL)技术测量前列腺癌血流量(BF)的可行性,并分析选择不同反转时间(TI)对测量值的影响。方法对经病理证实为前列腺癌的患者47例进行ASL扫描,TI分别设为1 000、1 200、1 400、1 600ms,测量并比较前列腺癌区和非癌区的BF平均值。结果 TI为1 000、1 200、1 400、1 600ms时,前列腺癌区BF值分别为(121.70±22.90)ml/(100g·min)、(129.65±23.46)ml/(100g·min)、(126.37±23.77)ml/(100g·min)、(125.07±22.86)ml/(100g·min),均明显高于非癌区的BF值[(37.76±10.83)ml/(100g·min)、(41.58±10.90)ml/(100g·min)、(43.97±10.81)ml/(100g·min)、(45.46±10.69)ml/(100g·min),P均<0.01]。4种不同TI条件下癌区与非癌区BF差值的差异无统计学意义(F=0.87,P=0.24)。结论 ASL成像技术可以用于前列腺癌的血流量测量,不同TI值对前列腺癌区和非癌区BF差值的评估具有影响。更多还原

【Abstract】 Objective To investigate the feasibility of noninvasive arterial spin labeling(ASL)to detect the blood flow(BF)in prostate cancer with 4different inversion times(TI).Methods Forty-seven prostate cancer patients were performed MR scanning with ASL sequenc.BF in the cancerous and noncancerous area in prostate were compared in 4different inversion times(1 000,1 200,1 400,1 600ms).Results With the different TI,the mean BF values in the cancerous areas([121.70±22.90]ml/[100g·min],[129.65±23.46]ml/[100g·min],[126.37±23.77]ml/[100g·min],[125.07±22.86]ml/[100g·min])were significantly higher than those in the noncancerous regions([37.76±10.83]ml/(100g·min),[41.58±10.90]ml/(100g·min),[43.97±10.81]ml/(100g·min),[45.46±10.69]ml/(100g·min);all P<0.01).There was no statistical difference of BF among the four different TI(F=0.87,P=0.24).Conclusion The ASL sequence can be used to evaluate the BF value in prostate cancer,and TI may affect the ability of ASL in detection of prostate cancer.更多还原