【摘要】 目的:筛选柴葛解肌处方的抗炎活性部位。方法:采用昆明种小鼠,以二甲苯致小鼠耳廓肿胀实验和角叉菜胶致小鼠足趾肿胀实验考察柴葛解肌处方不同部位的抗炎作用以及对PGE₂含量的影响。结果:柴葛解肌处方乙酸乙酯和正丁醇部位对小鼠耳廓肿胀以及小鼠足趾肿胀有显著抑制作用,正丁醇部位在0.8·kg^-1时对小鼠肿胀耳廓抑制率为51.9%,对小鼠足趾肿胀抑制率为37.45%（P<0.01）,且其PGE₂含量显著减少（P<0.01）。结论:柴葛解肌处方正丁醇部位为其主要抗炎部位,能抑制小鼠耳廓和足趾肿胀,减少PGE₂含量。更多还原

【Abstract】 Objective: To screen the anti-inflammatory fraction of Chaige Jieji prescription. Methods: The auricle edema model was induced by dimethylbenzene and the paw edema model was induced by carrageenan in Kunming mice to study the anti-inflammatory effects of different fractions,and the content of proateglandin E₂（ PGE₂） was measured determined. Results: Acetic ether part and nbutyl alcohol part of Chaige Jieji prescription could relieve the auricle edema and paw edema. The inhibition rate of n-butyl alcohol part at the dose of 0. 8 g·kg^-1for the auricle edema and paw edema was 51. 9% and 37. 45%,respectively（ P < 0. 01）,and the content of PGE₂ was decreased significantly（ P < 0. 01）. Conclusion: n-Butyl alcohol part of Chaige Jieji prescription is the main active fraction,which can relieve auricle edema and paw edema,and decrease the content of PGE₂.更多还原