【摘要】 目的比较卡维地洛与传统的美托洛尔治疗儿童扩张型心肌病(DCM)的疗效。方法将该院2012-09~2015-01收治的62例DCM患儿采用分层随机法分为A、B两组,每组31例。两组均常规口服地高辛、利尿剂及卡托普利。在此基础上,A组口服卡维地洛,B组口服美托洛尔,治疗6个月。超声诊断仪观察各组治疗前后左心室舒张末期内径(LVEDD)、左心室射血分数(LVEF),X线平片检查心胸比率(T/Th),电化学发光法检验N端B型脑钠肽(NT-pro BNP)的变化。结果治疗前,A组与B组的LVEDD、LVEF、T/Th、NTpro BNP指标比较差异无统计学意义(P>0.05)。治疗6个月后各项指标均明显改善(P<0.05),A组LVEDD、NT-pro BNP改善程度优于B组(P<0.05),但两组LVEF、T/Th改善程度差异无统计学意义(P>0.05)。结论卡维地洛相对于美托洛尔在治疗儿童DCM中更有优势,尤其体现在LVEDD及NT-pro BNP指标的改善方面,值得临床推广。更多还原

【Abstract】 Objective To compare the effects of Carvedilol and Metoprolo in the treatment of dilated cardiomyopath( DCM) in children. Methods Sixty-two children with DCM were collected in our hospital from September2012 to January 2015,and were randomly divided into group A( carvedilol) and group B( metoprolo),with 31 cases in each group. Both groups were regularly treated with digoxin,diuretic and captoprilm. The improvements of left ventricular end diastolic dimension( LVEDD),left ventricular ejection fraction( LVEF),the cardiothoracic ratio measured by chest X-rayplain film( T / Th) and N-terminal pro-brain natriuretic( NT-pro BNP) were compared between the two groups before and 6 months after the treatment. Results There were no significant differences between the two groups in LVEF,T / Th and NT-pro BNP before the treatment( P > 0. 05). However,the above indicators showed significant improvements in both groups before and 6 months after the treatment( P < 0. 05). LVEDD and NT-pro BNP were improved much significantly in group A than those in group B( P < 0. 05). There were no significant differences between the two groups in LVEF and T / Th( P > 0. 05). Conclusion Compared with metoprolol,carvedilol has more advantages in treating children with DCM,particularly in improving LVEDD and NT-pro BNP indexs.更多还原