【摘要】 目的分析高间接胆红素血症患儿治疗前后生化指标变化情况,为临床诊治及预后判断新生儿高间接胆红素血症提供实验室依据。方法测定64例高间接胆红素血症患儿治疗前后部分生化指标,并与50名健康新生儿进行比较。结果 64例病例中首要病因是围产因素(50.0%)。高间接胆红素血症患儿总胆红素(TBIL)、间接胆红素(IBIL)、肌酸激酶(CK)、肌酶激酶-同工酶(CK-MB)、天门冬氨酸氨基转换酶(AST)、乳酸脱氢酶(LDH)、尿酶(UA)活性均有不同程度增高,治疗前后比较差异有统计学意义(P<0.05)。结论应加强对早期新生儿黄疸的监测,及时干预,减少心肌损伤,避免胆红素脑病的发生。更多还原

【Abstract】 Objective To observe the changes of biochemical indexes in neonates before and after the treatment of hyperbilirubinemia. Methods The serum levels of some biochemical indexes were examined in 64 cases of neonates before and after the treatment of hyperbilirubinemia. Fifty healthy neonates were taken as the control group.Results The main cause of neonatal hyperbilirubinemia is prenatal factors,accounting for 50. 0%. The serum levels of TBIL,IBIL,CK,CK-MB,AST,LDH and UA in the neonates with hyperbilirubinemia were significantly higher than those in the healthy neonates. There were significant differences in the above biochemical indexes in the neonates between before and after the treatment of hyperbilirubinemia( P < 0. 05). Conclusion Early monitoring of bilirubin thesaurismosis helps to reduce myocardial injury in neonates with hyperbilirubinemia and reduce the incidence of bilirubin encephalopathy.更多还原