【摘要】 目的对来宾市新生儿α-地中海贫血情况进行筛查,为来宾市α-地中海贫血的临床诊断及防治提供参考依据。方法收集2014-05~2015-04该院住院分娩的2 050例新生儿脐带血标本,采用琼脂糖凝胶电泳测定Hb Bart’s含量,分析新生儿α-地中海贫血的发生情况。结果 2 050例新生儿中共检出α-地中海贫血272例,阳性率为13.27%,其中静止型137例(50.37%),标准型129例(47.43%),Hb H 6例(2.20%)。结论利用琼脂糖凝胶电泳能快速、有效筛查新生儿α-地中海贫血。来宾市为α-地中海贫血高发区,需积极开展α-地中海贫血防治工作,提高出生人口素质。更多还原

【Abstract】 Objective To screen for α-thalassemia in the neonates in Laibin city,and to provide the evidence for the clinical diagnosis,prevention and treatment of the disease.Methods Umbilical cord blood was collected from 2 050 neonates in our hospital from May 2014 to April 2015.The Hb Bart’s contents of the neonates were determinated by the agarose gel electrophoresis.The incidence of neonates with α-thalassemia was calculated.Results Two hundrend and seventy-two cases with α-thalassemia were checked out from 2 050 neonates.The positive rate was13.27%,of which 137 cases(accounting for 50.37%)with static type,129 cases(accounting for 47.43%)with standard type,and 6 cases(accounting for 2.21%)with Hemoglobin H disease.Conclusion The agarose gel electrophoresis is an efficient method fror quickly screening out α-thalassemis in neonates.Laibin city is an area with a high incidence of α-thalassemia.Active prevention and controlling measures should improve the population quality in this area.更多还原