【摘要】 目的观察小剂量醒脑静注射液治疗中重型颅脑损伤患者的临床效果。方法采用单盲随机对照试验设计,将120例患者按随机数字表法分为两组,各60例。对照组给予常规治疗。治疗组在常规治疗基础上加用醒脑静注射液10 m L入液静滴,每日1次;通过对患者格拉斯哥昏迷指标(GCS)评分、手术患者颅内压测值、并发症的发生(肺部感染、消化道出血、癫痫)进行观察、比较。结果治疗组在提高GCS评分、降低颅内压、降低肺部感染发生率、消化道出血发生率等方面优于对照组(P<0.05)。在降低癫痫发生率方面,与对照组差异无统计学意义(P>0.05)。结论在中重型颅脑损伤患者的治疗中,通过使用小剂量醒脑静注射液,能够达到提高GCS评分、降低颅内压、降低肺部感染和消化道出血发生率的作用,并可降低治疗费用,改善预后,降低死亡率。更多还原

【Abstract】 Objective:To observe curative effect of low-dose Xingnaojing injection on severe craniocerebral injury patients.Methods:single blind randomized controlled trial design was used.120 patients were randomly divided into 2 groups,60 cases in each.The control group was given conventional treatment.The treatment group was added intravenous drip of 10 m L Xingnaojing injection,once per day.GCS scores,intracranial pressure,the occurrence of complications(pulmonary infection,hemorrhage of digestive tract,epilepsy) were observed and compared.Results:The treatment group was better than the control group in improving GCS scores,reducing intracranial pressure and the incidence of pulmonary infection and hemorrhage of digestive tract(P < 0.05).There was no significant difference in reducing the incidence of epilepsy(P > 0.05).Conclusion:In the treatment of patients with moderate or severe craniocerebral injury,the use of low-dose Xingnaojing injection(10 m L) can improve GCS scores,and reduce intracranial pressure and the incidence of pulmonary infection and hemorrhage of digestive tract,and it also can reduce the cost of treatment,improve prognosis and reduce mortality.更多还原