【摘要】 目的:探讨天麦消渴片联合盐酸二甲双胍片对糖耐量异常患者胰岛素抵抗、胰岛β细胞及肝脏脂肪含量的影响。方法:120例糖耐量异常患者,随机分为对照组和观察组,各60例。两组患者均给予生活方式干预,饮食控制,并治疗相关基础病如降压、调脂等。两组患者均口服盐酸二甲双胍片。随餐服,每次0.5 g,每日3次。观察组在对照组基础上口服天麦消渴片,1次2片,每日2次。4周为1个疗程,两组患者均治疗3个疗程。观察两组患者观察两组患者治疗前后空腹血糖(FBG),空腹血浆葡萄糖(FPG),餐后2 h血糖(2h PG),糖化血红蛋白(Hb A1c),空腹胰岛素(FINS),糖负荷2 h胰岛素(2hin S),胰岛素抵抗指数(HOMA-IR),胰岛素β细胞功能(HOMA-β),体质量指数(BMI),总胆固醇(TC),甘油三酯(TG),肝脏脂肪含量,临床疗效及治疗后转归情况,并记录不良反应的发生情况。结果:治疗前两组患者各项指标无明显差异。治疗后,对照组以及观察组各项指标均优于治疗前,且观察组指标改变程度均优于对照组,差异均有统计学意义(P<0.05)。观察组总有效率为100.00%,高于对照组的90.00%,差异有统计学意义(P<0.05)。治疗后,对照组出现3例2型糖尿病,2例正常糖耐量,观察组无2型糖尿病出现,出现6例转为正常糖耐量,改善情况显著优于对照组,差异均具有统计学意义(P<0.05)。两组患者不良反应发生率不具有统计学意义(P>0.05)。结论:天麦消渴片可治疗糖耐量异常患者胰岛素抵抗,改善胰岛素β细胞功能,显著降低患者各项生化指标,降低肝脏脂肪含量,有助患者减少2型糖尿病的发生率,且不良反应较少,安全性好,值得临床推广。更多还原

【Abstract】 Objective: To investigate the effect of Tianmai Xiaoke Tablet and Metformin Hydrochloride Tablets on insulin resistance on islet β cells and liver fat content of patients with impaired glucose tolerance. Methods: During March2012—June 2015 in our hospital,a total of 120 patients were randomly divided into control group and observation group,60 cases in each. Two groups were given lifestyle intervention and diet controland treated the treatment- related underlying diseases such as blood pressure,lipid and the like. All patients orally took Metformin Hydrochloride Tablets with meals,each 0. 5 g,3 times a day. Observation group added Tianmai Xiaoke Tablet,2 tablets,2 times a day. 4 weeks was for a course of treatment and the patients were treated for 3 courses. Before and after treatment,we observed fasting blood glucose( FBG),fasting plasma glucose( FPG),2- hour postprandial blood glucose( 2hP G),glycated hemoglobin( HbA 1c),fasting insulin( FINS),2 h glucose load insulin( 2hinS),insulin resistance index( HOMA- IR),insulin β- cell function( HOMA- β),body mass index( BMI),total cholesterol( TC),triglyceride( TG),liver fat content,clinical efficacy and treatment outcomeand record the occurrence of adverse reactions. Results: The two groups before the treatment showed no significant difference. After treatment,the control group and the observation group’s indicators were better than those before treatmentand the degree of change in the observation group was superior to that of the control group. The differences were statistically significant( P < 0. 05). The observation group ’s total effective rate was100. 00%,higher than 90. 00% of the control group. The difference was statistically significant( P < 0. 05). After treatment,the control group had three cases of type 2 diabetes,two cases with normal glucose tolerance. The observation group had no type 2 diabetes and six cases’ glucose tolerance turned to be normal. The improvement was significantly better than that of the control group and the differences were statistically significant( P < 0. 05). The incidence of adverse reactions in patients of two groups was not statistically significant( P > 0. 05). Conclusion: TianmaiX iaoke Tablets can treat insulin resistance of abnormal glucose tolerance patients and improve insulin β- cell function,significantly lower patients’ biochemical indicators,reduce liver fat content,and can help patients to reduce the incidence of type 2 diabetes.And there are less adverse reactions. It is worthy of promotion.更多还原