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醒脑静注射液对蛛网膜下腔出血术后神经功能及炎性因子的影响分析

Xingnaojing Injection on Nerve Function and Inflammatory Factors of Subarachnoid Hemorrhage Patients after Surgery

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【作者】 赵迪段旭东高璇高菲路营营王宏宇

【Author】 ZHAO Di;DUAN Xudong;GAO Xuan;GAO Fei;LU Yingying;WANG Hongyu;Department of Neurosurgery,The First Hospital of Hebei Medical University;TCM Surgery,Second hospital of Hebei Medical University;Internal Medicine - Neurology,Second Hospital of Hebei Medical University;Hebei Medical Center for Medical Equipment;Department of Neurosurgery,Tangshan Worker Hospital;

【机构】 河北医科大学第一医院神经外科河北医科大学第二医院中医外科河北医科大学第二医院神经内科河北省医用药品器械集中采购中心唐山市工人医院神经外科

【摘要】 目的:分析在蛛网膜下腔出血术后治疗中,醒脑静注射液对神经功能及炎性因子的影响,探讨醒脑静注射液在蛛网膜下腔出血治疗中的应用价值。方法:将80例接受手术治疗的蛛网膜下腔出血患者作为观察对象,以随机数字表法随机分为两组,每组40例。以术后常规治疗中未包括醒脑静注射液者为对照组,以术后常规治疗中包括醒脑静注射液者为观察组。对比两组临床临床治疗效果。结果:两组间术后在院期间死亡率比较,差异未见统计学意义(P<0.05)。两组术后当日GCS及NIHSS评分比较,差异未见统计学意义(P>0.05);而在而在治疗2周时,观察组GCS评分高于对照组,NIHSS评分低于对照组,差异存在统计学意义(P<0.05)。两组术后当日Hpa、VEGF及hs-CRP含量比较,差异未见统计学意义(P>0.05);而在而在治疗2周时,观察组Hpa、VEGF及hs-CRP含量均明显低于对照组,差异存在统计学意义(P<0.05)。结论:醒脑静注射液可显著的改善蛛网膜下腔出血术后患者的神经功能及炎性因子。

【Abstract】 Objective: To analyze Xingnaojing Injection affecting nerve function and inflammatory factors of the subarachnoid hemorrhage patients after surgery. Methods: Eighty patients who underwent surgical treatment of subarachnoid hemorrhage were as research object. With random number table method,the patients were randomly divided into two groups,40 cases in each group. Those treated with postoperative routine therapy without Xingnaojing Injection were as the control group and those with Xingnaojing Injection for the observation group. Compare the nerve function and inflammatory factors of two groups. Results: There was no statistically significant difference of mortality rate between the two groups( P < 0. 05). There was no statistically significant difference of GCS and NIHSS score between two groups after operation( P > 0. 05). But after 2 weeks treatment,the GCS score of observation group was higher than that of the control group and the NIHSS score was lower than the control group’s( P < 0. 05). There was no statistically significant difference of Hpa,VEGF and hs- CRP levels between two groups after operation( P > 0. 05). But after 2 weeks treatment,the levels of Hpa,VEGF and hs- CRP of observation group were significantly lower than the control group’s and the difference was statistically significant( P < 0. 05). Conclusion: Xingnaojing Injection can significantly improve neural function and inflammatory factors of patients with subarachnoid hemorrhage.

【基金】 河北省卫生和计划生育委员会青年科技项目(20160706)
  • 【文献出处】 中华中医药学刊 ,Chinese Archives of Traditional Chinese Medicine , 编辑部邮箱 ,2016年07期
  • 【分类号】R651.12
  • 【被引频次】4
  • 【下载频次】91
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