【摘要】 目的:评价中药肠炎康颗粒治疗溃疡性结肠炎的疗效并通过对治疗前后患者肠黏膜中ICAM-1和MMP-9的表达变化探讨其可能的治疗机理。方法:选取2013年1月—2014年1月在沈阳军区总医院门诊就诊的活动期溃疡性结肠炎患者70例,随机分为中药组、西药组,每组35例,中药组予肠炎康颗粒加减;西药组予美沙拉嗪缓释颗粒。8周后对比两组的症状综合疗效及肠黏膜ICAM-1、MMP-9蛋白表达水平,并进行安全性评价。结果:最终中药组28例、西药组30例完成临床观察。两组患者临床主要症状治疗后较治疗前明显均好转,差异有统计学意义(P<0.05),中药组较西药组明显,组间差异有统计学意义(P<0.05);黏膜表现、综合疗效治疗后较治疗前好转,其积分差异有统计学意义(P<0.05),中药组更好,但组间差异无统计学意义(P>0.05);两组治疗前肠黏膜ICAM-1、MMP-9蛋白表达水平差异无统计学意义(P>0.05),治疗后均明显下降,差异有统计学意义(P<0.05),但组间对比差异无统计学意义(P>0.05)。西药组1例患者(3.33%)出现恶心,余患者未出现不良反应。两组患者治疗前后血、尿常规,肝、肾功,心电图均未见明显异常。结论:肠炎康颗粒治疗活动期溃疡性结肠炎疗效好,安全性好,其治疗机理可能与下调肠黏膜中ICAM-1、MMP-9的表达有关。更多还原

【Abstract】 Objective: To evaluate the clinical effect of Changyankang granules in treatment of patients with ulcerative colitis( UC) and explore its possible therapeutic mechanism by the ICAM- 1 and MMP- 9 expressions in intestinal mucosal before and after treatment. Methods: 70 patients with active UC were randomly divided into Chinese medicine group and western medicine group,35 cases in each group. The Chinese medicine group was treated with Changyankang granules and the western medicine group with mesalazine. After 8 weeks,we compared two groups’ comprehensive clinical symptoms and ICAM- 1 and MMP- 9 expressions in intestinal mucosa and evaluated its safety. Results: Finally,the Chinese medicine group’s 28 cases and the western medicine group; ’s 30 cases completed the study. All the patients were obviously improved than prior treatment in main clinical symptoms and the difference was statistically significant( P < 0.05). Compared with the western medicine group,the Chinese medicine group had better effect,but there was no significant difference between two groups( P > 0. 05). Mucosal manifestation and comprehensive effect were improved after treatment and its score difference was statistical significance( P < 0. 05). The Chinese medicine group was better,but there was no statistical significance( P > 0. 05). The ICAM- 1 and MMP- 9 expressions in intestinal mucosa were decreased obviously and the difference was statistically significant( P < 0. 05),but no statistical significance between groups( P > 0. 05). One patient of the western medicine group( 3. 33%) felt nauseated while the others had no adverse reactions occurred. Two groups’ blood,urine,liver function,renal function and electrocardiogram showed no obvious abnormalities. Conclusion: Changyangkang Granules have good effects and good safety in the treatment of active UC. The possible mechanism might be related to the down- regulation expressions of ICAM- 1 and MMP- 9.更多还原