【摘要】 目的:分析中医辨证和吉西他滨+顺铂对非小细胞肺癌患者的联合治疗效果,为临床研究提供新的思路。方法:将收集到的患者分成两组,全部接受吉西他滨+顺铂治疗,GP+中医组患者在此基础上接受中医辨证治疗,按照患者的不同分型对其使用相应的药物进行治疗,200 m L/d,1次/d,以21 d为1个疗程,共4个疗程。对比两组经过不同方案治疗后的WHO效果和中医症候效果,以及其各自在治疗过程中产生的不良症状。结果:中医+GP组的CR和PR患者所占人数比例显著比GP组高(P<0.05);中医+GP组的患者经过GP方案联合中医辨证治疗后的总有效率明显比单独使用GP方案的GP组要高(P<0.05);GP+中医组产生不良症状的患者比例都比GP组要小(P<0.05),中位生存期和治疗后的生存质量都明显比GP组要高(P<0.05)。结论:中医辨证和GP联合治疗中晚期非小细胞肺癌能够明显提高患者的客观缓解率,并显著降低患者产生不良症状的几率,具有较好的治疗效果。更多还原

【Abstract】 Objective: To observe and analyze the clinical effect of TCM syndrome differentiation and GP regimen in the treatment of middle or late stage non-small cell lung cancer. Methods: Collected patients divided into two groups and received gemcitabine and cisplatin in the treatment and GP +Chinese medicine group of patients based on accepted the syndrome differentiation and treatment of traditional Chinese medicine,according to patients with different types of the use of drugs for treatment. 200 m L / d,1 times / D,21 d for a course of treatment,a total of four courses. To compare the efficacy of WHO in the two groups,and the symptoms of TCM symptoms,and the symptoms during the treatment. Results: The proportion of the number of medicine and the contrast group of patients with Cr and PR significantly than the GP group high( P<0.05); traditional Chinese medicine contrast group patients after GP regimen combined with TCM syndrome differentiation and treatment of total efficiency obviously than the single use of GP regimen and GP were higher( P<0.05);GP + TCM group produced the proportion of patients with adverse symptoms are than the GP group to small( P< 0.05),median survival and quality of life after treatment were significantly higher than those in the GP group( P< 0. 05). Conclusion: Small cell lung cancer can significantly improve patients’ objective response rate and significantly reduced in patients with the probability of adverse symptoms of the syndrome differentiation of traditional Chinese medicine and GP combination therapy in advanced asymmetry has a better therapeutic effect.更多还原