【摘要】 目的:探究晚期消化道肿瘤癌因性疲乏患者应用中医辨证治疗的疗效,分析患者生活质量改善状况。方法:将2012年12月—2014年12月治疗的127例晚期消化道肿瘤癌因性疲乏患者,按照随机数表法分为:治疗组和对照组。治疗组65例,对照组62例。治疗组在给予对症处理的基础上,辅之以辨证中药方。对照组只给予单纯的对症处理。治疗时间为2周。患者治疗前后均接受近期疗效、疲乏状况、生活质量评定。两组患者的近期疗效参照WHO实体肿瘤客观疗效评价标准进行评价。患者疲乏状况评定采用PIPER-疲乏量表(piper fatigue scale,PFS)。两组患者的生活质量的评定采用EORTC QLQ-C30(version3.0)中文版评价。结果:对比两组患者治疗前的疲乏状况,治疗组与对照组都有不同程度的疲乏,差异不具统计学意义(P>0.05);比较治疗组治疗前后疲乏程度,疲乏症状明显减轻(P<0.05),比较对照组治疗前后疲乏程度,疲乏情况缓解效果不显著(P>0.05)。比较治疗组与对照组两组患者在功能领域的疗效,躯体功能、情绪功能、总健康状况差异显著(P<0.05),很明显治疗组治疗效果更佳。在改善疲乏、减轻疼痛、促进睡眠方面,治疗组比对照组获得更好的治疗效果,两组患者差异具有统计学意义(P<0.05)。结论:中医辨证治疗可显著改善晚期消化道肿瘤癌因性疲乏患者治疗效果,提高患者生活质量。更多还原

【Abstract】 Objective: To investigate the effect of TCM treatment of related fatigue of advanced gastrointestinal cancer cancer patients and analyze the quality of life of patients to improve the situation. Methods: 127 cases of advanced gastrointestinal cancer related fatigue patients who came to our hospital during December 2012 to December2014 were divided into the treatment group 65 patients and the control group 62 patients according to a random number table method. The treatment group was supplemented by dialectical prescription on the basis of given symptomatic treatment. The control group was given symptomatic treatment alone. Treatment time was two weeks. Patients received weight,short- term effect,tired status,quality of life assessments before and after treatment. Short- term efficacy of the two groups was evaluated according to WHO solid tumor objective response evaluation criteria. Fatigue condition of the patient was assessed using PIPER- Fatigue Scale( piper fatigue scale,PFS). The life quality of two groups patients were assessed using EORTC QLQ- C30( version3. 0) Chinese version of the review. Results: Compared the fatigue condition of two groups before the treatment,both the groups had different levels of fatigue and the difference was not statistically significant( P >0. 05). Compared the degree of fatigue before and after treatment,fatigue symptoms significantly reduced( P < 0. 05).Compared the degree of fatigue of the control group before and after treatment,relieve fatigue situation had no significant effect( P > 0. 05). Comparison of efficacy of the treatment group and the control group in functional areas,physical function,emotional function and overall health status were significantly different( P < 0. 05). The treatment group was obviously better. Improved fatigue,relieve pain and promote sleep of the treatment group got better than the control group’s.Two groups were statistically significant difference( P < 0. 05). Conclusion: TCM treatment can significantly improve the advanced gastrointestinal cancer or cancer fatigue and improve the life quality of patients.更多还原