【摘要】 目的:研究神经外科术后颅内感染的发生因素,以及临床治疗方法和效果。方法:将本院收治的神经外科术后颅内感染患者43例作为研究对象,回顾一般资料和治疗方法,分析总结危险因素。根据脑脊液细菌培养和药敏试验结果选择抗生素治疗,同时应用利奈唑胺,观察患者的临床治疗效果和不良反应,比较实验室指标变化情况。结果:导致感染发生的危险因素包括脑脊液漏、脑室引流、幕下手术、手术时间>4 h、使用显微镜等。患者治疗后共计有效率为93.0%,用药过程中没有肝肾功能损害发生,不良反应发生率为7.0%,对症处理后好转。患者治疗后白细胞、多核细胞、蛋白质指标明显降低、葡萄糖水平明显升高,和治疗前相比差异有统计学意义(P<0.05)。结论:神经外科手术患者术后颅内感染发生率高,且危险因素较多。患者在治疗中加用利奈唑胺效果确切,能够控制感染发展、改善生化指标,且不良反应发生少,值得推广。更多还原

【Abstract】 Objective:To study the occurrence of postoperative intracranial infection in neurosurgery factors,and clinical treatment methods and effects.Method:In our hospital 43 patients with neurosurgical postoperative intracranial infection were selected as research objects,review the general information and treatment methods,and risk factors were summarized.According to the result of cerebrospinal fluid bacterial culture and drug sensitive test choose antibiotic treatment,at the same time,application of rina thiazole amine,observe the patient’s clinical curative effect and adverse reaction,comparative laboratory index changes.Result:Infection risk factors included cerebrospinal fluid leakage,ventricle drainage,tentorium surgery,surgery time > 4 h,using microscope,etc.After treatment,the total effective rate was 93.0%,the drug without kidney function damage occurred in the process,the incidence of adverse reactions was 7.0%,improved after symptomatic treatment.After treatment,white blood cells,multinucleated cells,protein index decreased obviously,glucose levels increased significantly,compared before treatment there was statistically significant difference(P<0.05).Conclusion:Patients in the surgery of high incidence of postoperative intracranial infection,risk factors and more.Patients in the treatment of China-Canada with rina thiazole amine effect is exact,development can control infection,improve the biochemical indicators,and less adverse reactions occur,which is worth promoting.更多还原