【摘要】 目的:调查新入院精神分裂症患者有兴奋激越症状的比例,探索兴奋激越症状发生的相关因素。方法:本研究为多中心、横断面研究。在11家医院纳入新入院(入院时间24 h内)的精神分裂患者,采用自编一般情况调查表、CGI-S、PANSS-EC和MOAS量表进行评估,其中PANSS-EC总分≥14分,且至少有一条目得分≥4分定义为激越,PANSS-EC总分≥20分定义为严重激越。结果:最终纳入1115例患者,其中717例(64.3%)有兴奋激越症状,346例(31.0%)有严重激越症状。多因素logistic分析显示,入院前一周明显攻击行为(OR=7.49,95%CI:5.58~10.07)、非自愿住院(OR=1.66,95%CI:1.16~2.36)和CGI-S评分高(OR=1.39,95%CI:1.15~1.69)是兴奋激越的危险因素。结论:本研究提示新入院精神分裂症患者有兴奋激越症状的比例可能较高,入院前一周有明显攻击行为是兴奋激越症状的重要因素。更多还原

【Abstract】 Objective: To investigate the rate of agitation among newly hospitalized patients with schizophrenia,and to explore possible risk factors related to agitation. Methods: It w as a hospital-based survey study in11 psychiatric hospitals. Information about agitation of all enrolled patients w ere assessed w ith a self-compiled questionnaire about general demographic data and illness characteristics,the Clinical Global Impression-Severity( CGIS),Positive and Negative Syndrome Scale-Excited Component( PANSS-EC) and M odified Overt AggressionScale( M OAS). Results: In the 1115 patients involved in the study,717( 64. 3%) w ere agitated,and 346(31. 0%) severely agitated. The related factor to agitation was the history of aggressive behavior(OR = 7. 49,95% CI: 5. 58- 10. 07),higher CGI score( OR = 1. 39,95% CI: 1. 15- 1. 69) and involuntary hospitalization(O R = 1. 66,95% CI: 1. 16- 2. 36). Conclusions: The rate of agitation among newly hospitalized schizophrenic patients may be quite high,especially in those w ith history of aggressive behavior.更多还原